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首页> 外文期刊>Drug Design, Development and Therapy >Steroids as an adjunct for reducing the incidence of proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery: a?systematic review and meta-analysis
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Steroids as an adjunct for reducing the incidence of proliferative vitreoretinopathy after rhegmatogenous retinal detachment surgery: a?systematic review and meta-analysis

机译：类固醇作为减少流源性视网膜脱离手术后增生性玻璃体视网膜病变发生率的辅助手段：系统评价和荟萃分析

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Background: This meta-analysis was performed to determine the effectiveness of steroids as an adjunct following rhegmatogenous retinal detachment (RRD) surgery. Methods: RRD patients with or without proliferative vitreoretinopathy (PVR) were included. The treatment group included patients in whom steroids were used as an adjunct and a control group in which placebo was used. Only randomized controlled trials were included. We searched the main electronic databases and included studies published until July 2014. PVR odds ratio, visual acuity, retinal reattachment rate, and complications were evaluated in three trials. Results: Three randomized controlled trials were included in the meta-analysis. There was no significant difference in the incidence of postoperative PVR between groups (heterogeneity I2=48%, P=0.14). However, the incidence of postoperative PVR was lower in the treatment group (I2=0%, P<0.0001) than in the control group when a PVR grade C study was excluded. There was no statistically significant difference in postoperative visual acuity between the treatment and control groups (odds ratio -0.18; 95% confidence interval -0.38, 0.02; P=0.08). The two groups had similar results for primary/final retinal reattachment and reoperation rate. There was no significant difference in postoperative intraocular pressure. Conclusion: This systematic review demonstrates that steroids may significantly reduce the incidence of postoperative PVR grade B or lower following RRD surgery.
机译：背景：进行这项荟萃分析，以确定类固醇作为类风湿性视网膜脱离（RRD）手术后的辅助治疗的有效性。方法：包括或不包括增生性玻璃体视网膜病变（PVR）的RRD患者。治疗组包括使用类固醇作为辅助药物的患者和使用安慰剂的对照组。仅包括随机对照试验。我们搜索了主要的电子数据库，并纳入了截至2014年7月的研究。在三项试验中评估了PVR的优势比，视敏度，视网膜复位率和并发症。结果：荟萃分析包括三项随机对照试验。两组之间术后PVR的发生率无显着差异（异质性I2 = 48％，P = 0.14）。然而，当排除PVR C级研究时，治疗组的术后PVR发生率较低（I2 = 0％，P <0.0001），而对照组则较低。治疗组和对照组之间的术后视敏度无统计学差异（几率-0.18; 95％置信区间-0.38，0.02; P = 0.08）。两组在原发/终末视网膜复位和再手术率方面的结果相似。术后眼压无明显差异。结论：该系统评价表明，类固醇激素可显着降低RRD手术后术后PVR B级或更低的发生率。

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