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首页> 外文期刊>Diseases >The Predictive Value of Plasma Brain Natriuretic Peptide and Galectin-3 in Elderly Patients Admitted for Heart Failure ?
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The Predictive Value of Plasma Brain Natriuretic Peptide and Galectin-3 in Elderly Patients Admitted for Heart Failure ?

机译：血浆心钠肽和Galectin-3在老年心衰患者中的预测价值。

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Galectin-3 is demonstrated to be a robust independent marker of cardiovascular mid-term (18-month) outcomes in heart failure (HF) patients. The aim of this study was to analyze the value of a pre-discharged determination of galectin-3 alone and with brain natriuretic peptide (BNP) in predicting mid-term outcomes in elderly patients (70 years old) discharged after an acute decompensated HF (ADHF) episode. Methods: all elderly (≥70 years old) HF subjects discharged alive after an ADHF were enrolled. All patients underwent a determination of BNP and galectin-3, a 6-min walking test (6MWT), and an echocardiogram within 48 h of hospital discharge. Cardiac death, cardiac transplantation, and worsening heart failure requiring readmission to hospital were considered cardiovascular events. Results: 84 patients (63 males (75%), age 77.5 ± 5.9 years old) were analyzed (mean follow-up: 16.2 ± 12.3 months). During the follow-up, 45 events (53.6%) were scheduled (18 cardiac deaths, 27 re-hospitalizations for ADHF). HF patients who suffered an event demonstrated more impaired ventricular function ( p = 0.04), higher value of BNP ( p = 0.02), and Gal-3 at a pre-discharge evaluation ( p = 0.05). By choosing adequate cut-off points (BNP ≥ 500 pg/mL and Gal-3 ≥ 17.6 ng/mL), the Kaplan–Meier curves depicted a powerful stratification using Galectin-3 17.6 ng/mL alone (log-rank 13.22; p = 0.0003), and by adding BNP + Gal-3, an even better result was obtained (log-rank 17.96; p 0.00001). Conclusion: in an elderly population, by adding Gal-3 to BNP, a single pre-discharge strategy testing seemed to obtain a satisfactorily predictive value in alive HF patients discharged after an ADHF episode.
机译：Galectin-3被证明是心力衰竭（HF）患者心血管中期（18个月）结局的有力独立指标。这项研究的目的是分析单独进行半乳糖凝集素3和脑钠肽（BNP）的出院测定在预测急性失代偿性HF后出院的老年患者（> 70岁）的中期结局中的价值。 （ADHF）情节。方法：所有老年（≥70岁）HF患者在ADHF后均存活。所有患者在出院后48小时内均接受BNP和galectin-3的测定，6分钟步行测试（6MWT）和超声心动图。心脏死亡，心脏移植和需要入院的心力衰竭加重被认为是心血管事件。结果：分析了84例患者（63例男性（75％），年龄77.5±5.9岁）（平均随访时间：16.2±12.3个月）。在随访期间，计划了45例事件（53.6％）（18例心脏死亡，27例ADHF住院治疗）。在出院前评估中，发生事件的HF患者表现出更严重的心室功能受损（p = 0.04），BNP值较高（p = 0.02）和Gal-3（p = 0.05）。通过选择适当的临界点（BNP≥500 pg / mL，Gal-3≥17.6 ng / mL），Kaplan–Meier曲线描述了单独使用Galectin-3> 17.6 ng / mL时的有效分层（对数秩13.22; p = 0.0003），并且通过添加BNP + Gal-3，获得了更好的结果（log-rank 17.96; p <0.00001）。结论：在老年人群中，通过向BNP中添加Gal-3，单次放电前策略测试似乎对ADHF发作后出院的活着HF患者具有令人满意的预测价值。

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