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首页> 外文期刊>Drug Design, Development and Therapy >Current research for a vaccine against Lassa hemorrhagic fever virus
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Current research for a vaccine against Lassa hemorrhagic fever virus

机译：抗拉沙出血热病毒疫苗的最新研究

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Lassa virus (LASV) is a rodent-borne arenavirus endemic to several West African countries that causes Lassa fever (LF). LF is typically mild but it can cause severe disease characterized by hemorrhagic fever and multi-organ failure. A current outbreak of LASV in Nigeria has seen greater than 300 cases with a case fatality rate of 22%. Currently, there are limited treatment options and no vaccine candidates are approved to prevent LASV infection. The Coalition for Epidemic Preparedness Innovations has identified LASV as an emerging pathogen of high consequence and this has resulted in a push for several preclinical vaccine candidates to be advanced toward clinical trials. Here, we discuss several important aspects of LASV infection including immunobiology, immune evasion, and correlates of protection against LF, which have been identified through animal models and human infections. In addition, we discuss several vaccine candidates that have shown efficacy in animal models that could be advanced toward clinical trials. The increased fatality rate seen in the recent LASV outbreak in Nigeria highlights the importance of developing effective treatment and prevention strategies against LF. The spike in LASV cases seen in West Africa has the potential for increased mortality and human-to-human transmission, making the development and testing of effective vaccines for LASV critical.
机译：拉萨病毒（LASV）是一种在啮齿动物中传播的戊型肝炎病毒，在几个西非国家流行，导致拉萨热（LF）。 LF通常是轻度的，但会引起以出血热和多器官衰竭为特征的严重疾病。当前在尼日利亚爆发的LASV病例超过300例，病死率为22％。当前，治疗选择有限，并且没有批准用于预防LASV感染的候选疫苗。流行病防范创新联盟已将LASV鉴定为具有重大后果的新兴病原体，这促使推动了一些临床前疫苗候选者进入临床试验。在这里，我们讨论了LASV感染的几个重要方面，包括免疫生物学，免疫逃逸以及针对LF的保护相关性，这些已通过动物模型和人类感染得到了确认。此外，我们讨论了几种候选疫苗，这些候选疫苗在动物模型中显示出了功效，可以推进临床试验。最近在尼日利亚爆发的LASV病死率上升，突显了制定针对LF的有效治疗和预防策略的重要性。在西非看到的LASV病例激增有可能增加死亡率和人对人的传播，这使得开发和测试LASV有效疫苗变得至关重要。

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