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首页> 外文期刊>Drug Design, Development and Therapy >Systematic elucidation of the mechanism of geraniol via network pharmacology
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Systematic elucidation of the mechanism of geraniol via network pharmacology

机译：通过网络药理学系统阐明香叶醇的机理

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Background: Geraniol is an acyclic monoterpene alcohol, which is extracted from the ethereal oils of aromatic plants. A systematic analysis of its mechanism of action has not yet been carried out. Methods: In this study, the druggability of geraniol was assessed via Traditional Chinese Medicine Systems Pharmacology Database (TCMSP), and the potential targets of geraniol were identified using the Comparative Toxicogenomics Database (CTD). Additionally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses were performed using WebGestalt. Drug-target-pathway networks were constructed using Cytoscape to give a visual view. Results: Our findings showed that geraniol has superb druggability with 38 putative identified target genes. GO, KEGG, and network analyses revealed that these targets were associated with cancer, inflammatory immunoreactions, and other physiological processes. Conclusion: Geraniol is predicted to target multiple proteins and pathways that shape a network which can exert systematic pharmacological effects.
机译：背景：香叶醇是一种无环单萜醇，是从芳香植物的醚油中提取的。尚未对其作用机理进行系统分析。方法：在这项研究中，通过中药系统药理数据库（TCMSP）评估了香叶醇的可药用性，并使用比较毒物基因组学数据库（CTD）确定了香叶醇的潜在靶标。此外，使用WebGestalt进行了基因本体论（GO）和《京都议定书基因与基因组百科全书》（KEGG）途径分析。使用Cytoscape构建了药物-靶标-通路网络以提供视觉视图。结果：我们的研究结果表明，香叶醇具有38种推定的已鉴定靶基因，具有极好的可药用性。 GO，KEGG和网络分析表明，这些靶标与癌症，炎症性免疫反应和其他生理过程有关。结论：香叶醇被认为可靶向多种蛋白和形成网络的药理途径，这些网络可以发挥系统的药理作用。

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