This review describes the dose-dependent health benefits of resveratrol, a polyphenolic antioxidant that is found in a variety of foods, especially grape skin and red wine. Resveratrol provides diverse health benefits including cardioprotection, inhibition of low-density lipoprotein, activation of nitric oxide (NO) production, hindering of platelet aggregation [32] A.A.E. Bertelli, D.E. Giovannini, R.L. Caterina, W. Bernini, M. Migliori and M. Fregoni et al. , Antiplatelet activity of cis-resveratrol, Drugs Exp Clin Res 22 (1996), pp. 61–63. View Record in Scopus | Cited By in Scopus (111) and promotion of antiinflammatory effects. Studies have shown that at a lower dose, resveratrol acts as an anti-apoptotic agent, providing cardioprotection as evidenced by increased expression in cell survival proteins, improved post-ischemic ventricular recovery and reduction of myocardial infarct size and cardiomyocyte apoptosis and maintains a stable redox environment compared to control. At higher dose, resveratrol acts as a pro-apoptotic compound, inducing apoptosis in cancer cells by exerting a death signal. At higher doses, resveratrol depresses cardiac function, elevates levels of apoptotic protein expressions, results in an unstable redox environment, increases myocardial infarct size and number of apoptotic cells. At high dose, resveratrol not only hinders tumor growth but also inhibits the synthesis of RNA, DNA and protein, causes structural chromosome aberrations, chromatin breaks, chromatin exchanges, weak aneuploidy, higher S-phase arrest, blocks cell proliferation, decreases wound healing, endothelial cell growth by fibroblast growth factor-2 (FGF-2) and vascular endothelial growth factor, and angiogenesis in healthy tissue cells leading to cell death. Thus, at lower dose, resveratrol can be very useful in maintaining the human health whereas at higher dose, resveratrol has pro-apoptotic actions on healthy cells, but can kill tumor cells.
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机译：这篇评论描述了白藜芦醇的剂量依赖性健康益处，白藜芦醇是一种多酚抗氧化剂，可在多种食品中找到，尤其是葡萄皮和红酒。白藜芦醇具有多种健康益处，包括心脏保护，抑制低密度脂蛋白，激活一氧化氮（NO）生成，阻碍血小板聚集[32] A.A.E.。伯特利（D.E.） Giovannini，R.L。Caterina，W.Bernini，M.Migliori和M.Fregoni等。 ，顺式白藜芦醇的抗血小板活性，Drugs Exp Clin Res 22（1996），第61-63页。查看Scopus中的记录|在Scopus（111）中被引用并具有抗炎作用。研究表明，在较低剂量下，白藜芦醇可作为抗凋亡剂，提供心脏保护作用，如细胞存活蛋白表达增加，缺血后心室恢复改善，心肌梗死面积和心肌细胞凋亡减少以及维持稳定的氧化还原所证明的那样。环境相比于控制。在较高剂量下，白藜芦醇充当促凋亡化合物，通过施加死亡信号诱导癌细胞凋亡。在较高剂量下，白藜芦醇会降低心脏功能，提高凋亡蛋白表达水平，导致不稳定的氧化还原环境，增加心肌梗塞面积和凋亡细胞数量。高剂量时，白藜芦醇不仅会阻碍肿瘤的生长，而且会抑制RNA，DNA和蛋白质的合成，导致结构染色体畸变，染色质断裂，染色质交换，非整倍体性弱，S期阻滞高，阻止细胞增殖，降低伤口愈合，内皮细胞通过成纤维细胞生长因子2（FGF-2）和血管内皮生长因子的生长，以及健康组织细胞中的血管生成导致细胞死亡。因此，在较低剂量下，白藜芦醇对维持人类健康非常有用，而在较高剂量下，白藜芦醇对健康细胞具有促凋亡作用，但可以杀死肿瘤细胞。
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