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首页> 外文期刊>Dose-response >Hormetic Effects of Reactive Oxygen Species by Exercise: A View from Animal Studies for Successful Aging in Human
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Hormetic Effects of Reactive Oxygen Species by Exercise: A View from Animal Studies for Successful Aging in Human

机译：运动引起的活性氧的兴奋效应：从动物研究中成功获得人类衰老的观点

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Numerous anti-aging measures have been proposed to cope with age-associated decline of physiological functions and/or onset of diseases, mostly based on free radical (or oxidative stress) theory of aging, though no robust scientific data have been reported to extend human healthspan. This is due to dual (harmful as well as essential) roles of reactive oxygen species (ROS) to a body. Regular moderate exercise provides benefits upregulating defense against oxidative stress in good balance between the opposing dual roles. Sources of ROS in exercise appear to be not only mitochondria as often claimed but also enzymatic reactions catalyzed by NADPH oxidase and other oxidases. It may, therefore, be possible to mimic this aspect of exercise to promote the defense for healthspan extension by other means such as modest alcohol consumption that could upregulate activity of enzymes against oxidative stress.
机译：已经提出了许多抗衰老措施来应对与年龄相关的生理功能下降和/或疾病发作，主要是基于衰老的自由基（或氧化应激）理论，尽管尚无可靠的科学数据报道可延长人类寿命健康期。这是由于活性氧（ROS）对人体的双重作用（有害的和必要的）。定期进行适度的运动有助于平衡抵抗双重作用之间的平衡，从而增强抵抗氧化应激的防御能力。运动中ROS的来源似乎不仅是经常声称的线粒体，还包括由NADPH氧化酶和其他氧化酶催化的酶促反应。因此，可能有可能模仿运动的这一方面，通过其他方式（例如适度饮酒）增强对健康跨度的防御，这可能会上调酶抗氧化应激的活性。

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