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Hormesis can and Does Work in Humans

机译：兴奋剂可以并且确实在人类中起作用

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If we accept the validity of the general concept of physiological hormesis as being the phenomenon of achieving health beneficial effects by exposure to mild stress, then hormesis is being applied already and successfully to humans. The evidence for this is the well-demonstrated health benefits of regular and moderate exercise. Mild stress-induced activation of one or more intracellular pathways of stress response are central to this. Experimental studies performed on human cells in culture exposed to mild heat shock and other stresses provide biochemical and molecular evidence in support of the application of hormesis to human systems. Although several issues remain to be resolved by more research with respect to the extent and duration of hormetic exposure, making use of the cellular stress response pathways can facilitate discovering novel hormetins for human applications.
机译：如果我们接受生理性兴奋剂的一般概念的有效性，认为它是通过暴露于轻度压力而达到有益健康的现象，那么兴奋剂已被成功地应用于人类。这证明了定期和适度运动对健康的好处。轻度压力诱导的一种或多种细胞内应激反应途径的激活对此至关重要。在暴露于轻度热冲击和其他压力的培养物中对人体细胞进行的实验研究提供了生物化学和分子证据，支持将兴奋剂应用于人体系统。尽管关于激素暴露的程度和持续时间的若干研究仍有待解决，但利用细胞应激反应途径可以促进发现适用于人类的新型激素。

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