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首页> 外文期刊>Drug Design, Development and Therapy >Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial
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Comparison of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia: a randomized controlled trial

机译：右美托咪定和舒芬太尼作为硬膜外分娩镇痛局部麻醉药佐剂的比较：一项随机对照试验

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Background: The epidural dexmedetomidine combined with ropivacaine has been successfully used for labor analgesia. We compared the effects of dexmedetomidine and sufentanil as adjuvants to local anesthetic for epidural labor analgesia. Methods: Eighty nulliparous women were enrolled in the double-blind study and randomly divided into two groups. Group D received 0.5 μg/mL dexmedetomidine with 0.1% ropivacaine for epidural labor analgesia, and group S (control group) received 0.5 μg/mL sufentanil with 0.1% ropivacaine for labor analgesia. Hemodynamic parameters were monitored. Pain was assessed using a visual analog scale. The onset of epidural analgesia, duration of stages of labor, Ramsay Sedation Scale, blood loss, neonatal Apgar scores, umbilical artery blood pH and adverse effects, such as respiratory depression, nausea, vomiting, pruritus, and bradycardia, were recorded. Results: Compared with the control group, visual analog scale values after cervical dilation 3 cm were lower in group D ( P 0.05) and first-stage labor duration was shorter in group D (378.5±52.6 vs 406.5±58.2, P 0.05). Ramsay Sedation Scale values were higher in group D compared to the control group (2.8±0.6 vs 2.4±0.5, P 0.05). No significant differences in side effects were observed between the groups. Conclusion: Dexmedetomidine is superior to sufentanil in analgesic effect and duration in first-stage labor during epidural analgesia when combined with 0.1% ropivacaine (www.chictr.org.cn, registration ChiCTR-OPC-16008548).
机译：背景：硬膜外右美托咪定联合罗哌卡因已成功用于分娩镇痛。我们比较了右美托咪定和舒芬太尼作为局部麻醉药对硬膜外分娩镇痛的辅助作用。方法：80名未生育妇女参加了双盲研究，随机分为两组。 D组接受0.5μg/ mL右美托咪定和0.1％罗哌卡因用于硬膜外分娩镇痛，S组（对照组）接受0.5μg/ mL舒芬太尼和0.1％罗哌卡因用于分娩镇痛。监测血流动力学参数。使用视觉模拟量表评估疼痛。记录硬膜外镇痛的发作，分娩的持续时间，Ramsay镇静量表，失血，新生儿Apgar评分，脐动脉血pH值以及诸如呼吸抑制，恶心，呕吐，瘙痒和心动过缓等不良反应。结果：与对照组相比，D组颈椎扩张> 3 cm时的视觉模拟量表值较低（P <0.05），D组的第一阶段劳动时间较短（378.5±52.6 vs 406.5±58.2，P < 0.05）。 D组的Ramsay镇静量表值高于对照组（2.8±0.6 vs 2.4±0.5，P <0.05）。两组之间未观察到明显的副作用差异。结论：与0.1％罗哌卡因联合使用时，右美托咪定在硬膜外镇痛的第一阶段分娩中的镇痛效果和持续时间优于舒芬太尼（www.chictr.org.cn，注册号ChiCTR-OPC-16008548）。

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