Complement system and age-related macular degeneration: drugs and challenges

Jiali Wu; Xiaodong Sun

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Complement system and age-related macular degeneration: drugs and challenges

机译：补体系统和年龄相关性黄斑变性：药物和挑战

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Age-related macular degeneration (AMD) is directly attributable to vision loss, posing significant pressure on public health. AMD is recognized to be a multi-factorial disease and among them, complement system is under heated discussion in recent years. In this review, we start with an overview of complement pathways involved in AMD and their therapies correspondingly. Finally, we discuss the development of the therapeutics existed now. Also, we enclose a list of drugs undergoing clinical trials.

机译：与年龄有关的黄斑变性（AMD）直接归因于视力丧失，对公共健康构成了巨大压力。 AMD被认为是一种多因素疾病，其中补体系统近年来受到热烈讨论。在本文中，我们首先概述了AMD及其治疗中涉及的补体途径。最后，我们讨论了目前存在的疗法的发展。另外，我们附上了正在进行临床试验的药物清单。

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《Drug Design, Development and Therapy》 |2019年第4期|共13页
作者
Jiali Wu; Xiaodong Sun;
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正文语种
中图分类药学;
关键词
age-related macular degenerationinflammationcomplement systemimmunotherapy;

机译：老年性黄斑变性炎症补充系统免疫治疗;

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1. Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population [J] . Ayala-Ramirez Raul, Bekker-Méndez Carolina, Buentello-Volante Beatriz, Molecular vision . 2012,第2012期

机译：墨西哥人群中与年龄相关的高级黄斑变性和补体因子H，补体因子B，补体成分2，补体成分3和年龄相关性黄斑病变易感性2基因的易感性
2. Re: Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group, et al.: Five-year outcomes with anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials (Ophthalmology 2016;123:1751-1761) Reply [J] . Maguire Maureen G. Ophthalmology . 2017,第3期

机译：Re：年龄相关黄斑变性治疗的比较试验（CATT）研究组，等人：抗血管内皮生长因子治疗新生血管年龄相关性黄斑变性的五年结果：年龄相关黄斑变性治疗的比较试验（2016年眼科; 123：1751-1761）回复
3. Re: Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Research Group, et al.: Five-year outcomes with antivascular endothelial growth factor treatment of neovascular age-related macular degeneration: The Comparison of Age-Related Macular Degeneration Treatments Trials (Ophthalmology 2016;123:1751-1761) [J] . Gillies Mark C., Daien Vincent, Nguyen Vuong, Ophthalmology . 2017,第3期

机译：Re：年龄相关的黄斑变性治疗试验（CATT）研究组，等人类的比较：抗病毒内皮生长因子治疗新生血管年龄相关黄斑变性的五年成果：年龄相关黄斑变性治疗试验的比较（ 2016年眼科学; 123：1751-1761）
4. Computational Modeling of Drug Delivery for Treatment of Age-Related Macular Degeneration [C] . N.G.Dimitrioglou, M.E.Kavousanakis, D.T.Hatziavramidis World Congress on Medical Physics and Biomedical Engineering . 2019

机译：药物递送治疗年龄相关性黄斑变性的计算模拟
5. Iron-induced complement dysregulation in the retinal pigment epithelium: implications for age-related macular degeneration [D] . Li, Yafeng 2015

机译：铁诱导的视网膜色素上皮的补体失调：与年龄相关的黄斑变性的影响
6. Complement system and age-related macular degeneration: drugs and challenges [O] . Jiali Wu, Xiaodong Sun 2019

机译：补体系统和与年龄有关的黄斑变性：药物和挑战
7. >Complement system and age-related macular degeneration: drugs and challenges [O] . Jiali Wu, Xiaodong Sun 2019

机译：>补体系统和年龄相关的黄斑变性：药物和挑战

Complement system and age-related macular degeneration: drugs and challenges

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