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首页> 外文期刊>Drug Design, Development and Therapy >Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study
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Very rapid effect of pitavastatin on microvascular function in comparison to rosuvastatin: reactive hyperemia peripheral arterial tonometric study

机译：与瑞舒伐他汀相比，匹伐他汀对微血管功能的作用非常迅速：反应性充血外周动脉眼压测量研究

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Background: It has been reported that pitavastatin improves endothelial function faster than other statins. Recently introduced reactive hyperemia peripheral arterial tonometry (RH-PAT) provides objective and quantitative assessment of peripheral microvascular function.Purpose: This study aimed to investigate whether peripheral microvascular function improved 2 hours after pitavastatin in subjects with coronary artery disease (CAD) using RH-PAT, and the results were compared with those of rosuvastatin.Methods: This study included 94 subjects with CAD, assigned to a group given 2 mg of pitavastatin (n = 36), a group given 2.5 mg of rosuvastatin (n = 38), and a control group (n = 20). RH-PAT examinations were performed before and 2 hours after statin administration.Results: The RH-PAT index increased 2 hours after pitavastatin administration from 1.82 ± 0.45 to 2.16 ± 0.62 (P = 0.02), whereas there were no differences in the RH-PAT index in the rosuvastatin group (1.79 ± 0.71 to 1.91 ± 0.53, P = 0.09) and the control group (1.68 ± 0.36 to 1.84 ± 0.58, P = 0.4). No significant changes were observed at 2 hours in serum cholesterol levels in each group.Conclusion: The present study demonstrated that peripheral microvascular function improved 2 hours after a single clinical dose of pitavastatin, but not after rosuvastatin.
机译：背景：据报道，匹伐他汀比其他他汀类药物改善内皮功能的速度更快。最近引入的反应性充血外周动脉眼压计（RH-PAT）提供了客观和定量的外周微血管功能评估。目的：本研究旨在研究在使用匹伐他汀治疗2个小时的冠心病（CAD）患者中，外周血微血管功能是否改善，使用RH-方法：本研究包括94名患有CAD的受试者，分为两组：分别给予匹伐他汀2 mg（n = 36），给予2.5 mg罗舒伐他汀（n = 38），对照组（n = 20）。他汀类药物给药前和给药后2小时进行RH-PAT检查。结果：匹伐他汀给药2小时后RH-PAT指数从1.82±0.45增加到2.16±0.62（P = 0.02），而RH-PAT则无差异罗苏伐他汀组（1.79±0.71至1.91±0.53，P = 0.09）和对照组（1.68±0.36至1.84±0.58，P = 0.4）的PAT指数。每组2小时的血清胆固醇水平均未观察到显着变化。结论：本研究表明，单次临床剂量匹伐他汀治疗2小时后外周微血管功能改善，但瑞舒伐他汀治疗后未见改善。

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