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Complete Technical Scheme for Automatic Biological Dose Estimation Platform

机译：生物剂量自动估算平台完整技术方案

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摘要

To establish a complete technical solution for the automatic radiation biological dose estimation platform for biological dose estimation and classification of the wounded in large-scale radiation accidents, the “dose–effect curve by dicentric chromosome (DIC) automatic analysis” was established and its accuracy was verified. The effects of analyzed cell number and the special treatment of the culture on dose estimation by DIC automatic analysis were studied. Besides, sample processing capabilities of the special equipments were tested. The fitted “dose–effect curve by DIC automatic analysis” was presented as follows: Y = (0.01806 ± 0.00032) Dsup2/sup + (0.01279 ± 0.00084) D + (0.0004891 ± 0.0001358) (Rsup2/sup = 0.961). Three-gradient scanning method, culture refrigeration method, and interprofessional collaboration under extreme conditions were proposed to improve the detection speed, prolong the sample processing time window, and reduce the equipment investment. In addition, the optimized device allocation ratio for the automatic biological dose estimation laboratory was proposed to eliminate the efficiency bottleneck. The complete set of technical solutions for the high-throughput automatic biological dose estimation laboratory proposed in this study can meet the requirements of early classification and rapid biological dose assessment of the wounded during the large-scale nuclear radiation events, and it is worthy of further promotion.
机译：为建立大规模放射事故中伤员生物剂量估算和分类的自动放射生物剂量估算平台的完整技术解决方案，建立了“双中心染色体自动分析剂量效应曲线”及其准确性已验证。通过DIC自动分析研究了分析细胞数和培养物的特殊处理对剂量估计的影响。此外，还测试了专用设备的样品处理能力。拟合的“通过DIC自动分析的剂量效应曲线”表示如下：Y =（0.01806±0.00032）D 2 +（0.01279±0.00084）D +（0.0004891±0.0001358）（R 2 = 0.961）。为了提高检测速度，延长样品处理时间，减少设备投资，提出了三梯度扫描法，培养制冷法和极端条件下的专业间协作。此外，为自动剂量估算实验室提出了优化的设备分配比例，以消除效率瓶颈。本研究提出的高通量生物剂量自动估计实验室的全套技术方案，可以满足大规模核辐射事件中伤者的早期分类和快速生物剂量评估的要求，值得进一步研究。晋升。

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