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Microscopic Colitis and Reproductive Factors Related to Exposure to Estrogens and Progesterone

机译：与暴露于雌激素和孕激素的微观结肠炎和生殖因子

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Microscopic colitis (MC) often debuts around or after menopause and is divided into lymphocytic- and collagenous colitis. The aim of this study was to examine whether factors influencing sex hormone levels differed between subgroups of MC as well as between patients and controls. A self-administered questionnaire about parity was completed which included questions surrounding age at first childbirth, menarche and menopause, the use of oral contraceptives, and hormonal replacement therapy. Patients with lymphocytic colitis had children less often compared to those with collagenous colitis (OR = 0.20, 95% CI = 0.05–0.86), however no differences were observed between patients with persistent or transient disease. Patients were less often older than 15 years of age at menarche (OR = 0.48, 95% CI = 0.26–0.91) and were younger at menopause (OR = 0.30, 95% CI = 0.16–0.56) compared with controls. Thus, no obvious association between factors influencing sex hormone levels and presence of MC could be found.
机译：显微镜结肠炎（MC）通常在更年期前后出现，分为淋巴细胞性和胶原性结肠炎。这项研究的目的是检查影响性激素水平的因素在MC亚组之间以及患者与对照之间是否存在差异。一份关于胎次的自我管理问卷已经完成，其中包括初生年龄，初潮和更年期，口服避孕药的使用以及激素替代疗法等问题。与胶原性结肠炎相比，淋巴细胞性结肠炎患者的孩子较少（OR = 0.20，95％CI = 0.05–0.86），但是持续性或短暂性疾病患者之间没有差异。与对照组相比，初潮年龄小于15岁的患者（OR = 0.48，95％CI = 0.26-0.91）少，绝经年龄较小的患者（OR = 0.30，95％CI = 0.16-0.56）。因此，没有发现影响性激素水平的因素和MC的存在之间的明显关联。

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