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Use of Antipsychotic Drugs by Elderly Primary Care Patients and the Effects of Medication Reviews: A Cross-Sectional Study in Sweden

机译：老年基层医疗患者使用抗精神病药物和药物评价的影响：瑞典的一项跨部门研究

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BackgroundAntipsychotics form a class of drugs that should be used with caution among elderly people because of a high risk of adverse events. Despite the risks and modest effects, their use is estimated to be high, especially in nursing homes. ObjectiveThe aim was to explore the effects of medication reviews on antipsychotic drug use for elderly primary care patients and describe the extent of, and reasons for, the prescription of antipsychotics. MethodsIn this cross-sectional study in primary care in Sk?ne, Sweden, patients aged ≥75 years living in nursing homes or in their own homes with home care were included. The effects of medication reviews were documented, as were the use of antipsychotics and the differences in characteristics between patients receiving or not receiving antipsychotics. ResultsA total of 1683 patients aged 87.6 (±5.7) years?were included in the analysis. Medication reviews reduced the use of antipsychotics by 23% ( p n =?93) had an approved indication, while for 15% ( n =?32) the indication was not given. Antipsychotic drug use was more common with increasing number of drugs ( p =?0.001), and in nursing home residents ( p ConclusionThe use of antipsychotic drugs is high in elderly patients in nursing homes. They are often given for indications that are not officially approved or are poorly documented. Medication reviews appear to offer one useful strategy for reducing excessive use of these drugs.
机译：背景抗精神病药是一类药物，由于不良事件的高风险，在老年人中应谨慎使用。尽管存在风险和影响不大，但估计使用率很高，尤其是在疗养院中。目的目的是探讨药物审查对老年初级保健患者抗精神病药物使用的影响，并描述抗精神病药物处方的范围和原因。方法在这项横断面研究中，在瑞典斯科讷进行的初级保健中，纳入了≥75岁居住在疗养院或自己在家中的家庭患者。记录了药物评论的效果，以及使用抗精神病药的情况以及接受或未接受抗精神病药的患者之间的特征差异。结果共纳入1683例年龄为87.6（±5.7）岁的患者。药物评论将抗精神病药的使用减少了23％（p n =？93）（有批准的适应症），而15％（n =？32）的患者没有给予适应症。抗精神病药物的使用随着药物数量的增加（p =？0.001）和疗养院居民的使用更为普遍（p结论结论抗精神病药物的使用在养老院的老年患者中较高，通常用于未得到正式批准的适应症药物审查似乎为减少这些药物的过度使用提供了一种有用的策略。

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