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首页> 外文期刊>Drug Target Insights >Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention
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Management of Diabetes Associated with Nephrotic Syndrome: Therapeutic Potential of Dapagliflozin for Protracted Volume Retention

机译：糖尿病合并肾病综合征的管理：Dapagliflozin延长容量保留的治疗潜力

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A 48-year-old female was admitted to our hospital presenting with a chief complaint of progressive swelling because of diabetic nephrotic syndrome. Dapagliflozin seemed to play a role in accelerating the patient’s urinary sodium excretion as well as reducing gross fluid retention despite the fact that her nephrotic condition was resistant to furosemide. Our experience emphasizes a potential novel approach to overcoming loop diuretic resistance using this agent among some subsets of type 2 diabetic subjects complicated with severe volume accumulation. We believe that combination treatment consisting of dapagliflozin and furosemide may produce diuretic synergy via sequential nephron blockade. The accumulation of more experience with additional cases similar to ours requires continuous and careful attention.
机译：一名48岁女性因糖尿病肾病综合征而住院，主诉进展性肿胀。达格列净似乎在加速患者尿钠排泄以及减少总体液retention留中起着作用，尽管她的肾病状况对速尿有抵抗力。我们的经验强调，在一些2型糖尿病受试者的一些子集中并伴有严重的血容量积聚的情况下，使用这种药物克服环利尿剂耐药性的潜在新方法。我们认为由达格列净和速尿组成的联合治疗可能会通过顺序性肾单位阻滞产生利尿协同作用。在与我们类似的其他案例中积累更多经验需要持续不断的关注。

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