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Brain Histamine N-Methyltransferase as a Possible Target of Treatment for Methamphetamine Overdose

机译：脑组胺N-甲基转移酶可能是治疗甲基苯丙胺过量的靶点

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Stereotypical behaviors induced by methamphetamine (METH) overdose are one of the overt symptoms of METH abuse, which can be easily assessed in animal models. Currently, there is no successful treatment for METH overdose. There is increasing evidence that elevated levels of brain histamine can attenuate METH-induced behavioral abnormalities, which might therefore constitute a novel therapeutic treatment for METH abuse and METH overdose. In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain. Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Consequently, this compound can be a candidate for a prototype of drugs for the treatment of METH overdose.
机译：甲基苯丙胺（METH）过量引起的刻板行为是METH滥用的明显症状之一，可以在动物模型中轻松评估。目前，尚无成功治疗过量甲乙砜的方法。越来越多的证据表明，升高的脑组织胺水平可以减轻METH引起的行为异常，因此可能构成METH滥用和METH过量的新型治疗方法。在哺乳动物中，组胺N-甲基转移酶（HMT）是负责降解大脑中组胺的唯一酶。 Metoprine是最有效的HMT抑制剂之一，可通过抑制HMT穿越血脑屏障并增加脑组胺水平。因此，该化合物可以作为治疗METH过量药物原型的候选药物。

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