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首页> 外文期刊>Drug Target Insights >Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery
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Gentamicin-Impregnated Collagen Sponge: Effectiveness in Preventing Sternal Wound Infection in High-Risk Cardiac Surgery

机译：庆大霉素浸渍的胶原蛋白海绵：预防高风险心脏手术中的胸骨伤口感染的有效性。

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摘要

Sternal wound infections represent one of the most frequent complications after cardiac surgery and are associated with high postoperative mortality. Several preventive methods have been introduced, and recently, gentamicin-impregnated collagen sponges (GICSs) have shown a promising effect in reducing the incidence of this type of complications. Gentamicin is an aminoglycoside antibiotic that has been widely used to treat infections caused by multiresistant bacteria; despite its effectiveness, its systemic use carries a risk of toxicity. GICSs appear to overcome this side effect, topically delivering high antibiotic concentrations to the wound and thus reducing the toxic-related events. Although several retrospective analyses and randomized controlled trials have studied the use of GICSs in cardiac surgery, conclusions regarding their efficacy in preventing sternal wound infection are inconsistent. We have reviewed the current literature focusing on high-risk patients.
机译：胸骨伤口感染是心脏手术后最​​常见的并发症之一，并与术后高死亡率相关。已经引入了几种预防方法，最近，庆大霉素浸润的胶原蛋白海绵（GICSs）在减少此类并发症的发生率方面显示出了有希望的效果。庆大霉素是一种氨基糖苷类抗生素，已被广泛用于治疗由多重耐药菌引起的感染。尽管有效，但其全身使用仍具有毒性风险。 GICS似乎可以克服这种副作用，可以向伤口局部输送高浓度的抗生素，从而减少与毒性有关的事件。尽管一些回顾性分析和随机对照试验已经研究了GICS在心脏外科手术中的使用，但是关于其在预防胸骨伤口感染中的功效的结论尚不一致。我们回顾了当前针对高风险患者的文献。

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