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首页> 外文期刊>Drug Target Insights >Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis
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Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis

机译：介绍性社论：药物洗脱支架还是药物洗脱移植物？蛋白质组学分析的见解

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Current Developments in Drug Eluting DevicesSupplement Aims and ScopeThis supplement is intended to focus on drug eluting devices. Devices (eg cardiovascular stents, drug delivery biopolymers and tissue engineering devices), their biocompatibility, and mechanisms of transport are included within the supplement's scope.Drug Target Insights aims to provide researchers working in this complex, quickly developing field with online, open access to highly relevant scholarly articles by leading international researchers. In a field where the literature is ever-expanding, researchers increasingly need access to up-to-date, high quality scholarly articles on areas of specific contemporary interest. This supplement aims to address this by presenting high-quality articles that allow readers to distinguish the signal from the noise. The editor in chief hopes that through this effort, practitioners and researchers will be aided in finding answers to some of the most complex and pressing issues of our time.The rapidly expanding panorama of prosthetic replacement and interventional procedures for cardiovascular disease demands significant research for the development of devices with optimized characteristics and performance to overcome the drawbacks of the existing strategies. Tissue engineering is a potent weapon in this scenario, enabling the realization of sophisticated biocompatible devices interacting with the host tissues and influencing their behavior. The fabrication and design of “smart” biomaterials, able to sense and interact with the biological milieu, represent a cornerstone in tissue engineering and regenerative medicine. This development has demolished the obsolete tenets of surgery implying reconstructing organs or part of them with artificial materials. The deeper understanding achieved by modern research has highlighted the limitations and the biological and clinical drawbacks of the long-term coexistence of a foreign material in the body, especially in the cardiovascular system.1 The need to respect the physiological reparative and remodeling processes normally occurring in nature progressively achieved significance in the current research,2,3 demonstrating the necessity to accompany the body's physiological responses and the activities of tissue regeneration rather than pretending to replace them with “plastic” surrogates. This attention to the biology of regeneration in tissue engineering and to micro-environmental conditions at the tissue and cellular levels is expressed in the articles of this special issue of Drug Target Insights. Interesting and sophisticated approaches are proposed in this context, entailing the use of drug-delivery devices that release tailored compounds to target specific aspects of diseases or complications. In this issue, Dr Rapetto and colleagues extensively reviewed the role of gentamicin-impregnated collagen sponges (GICSs) in preventing sternal wound infection. The use of these delivery devices allows for topical delivery of high antibiotic concentrations to the wound, reducing the complications associated with gentamycin toxicity.4 On the other side, alternative use of smart biopolymers able to release anticoagulant agents, such as heparin, to avoid early vascular graft thrombosis and failure will be presented and discussed in the same issue of the Journal.5 These are not the only applications in this field, as demonstrated by other papers in this issue. Indeed, at the experimental level, several research efforts have been engaged in designing scaffold-releasing factors, drugs or cytokines to improve tissue regeneration or stem cell recruitment, or to overcome prosthesis-related issues.6 The possibility to tailor a bioresorbable scaffold in order to create a microenvironment able to boost or guide tissue regeneration is an exciting area of investigation.7,8 Additionally, drug-releasing devices might also allow avoidance or treatment of some of the drawbacks related to prosthetic replacement
机译：药物洗脱设备的最新发展补充目的和范围本补充旨在聚焦于药物洗脱设备。器械的范围包括器械（例如心血管支架，药物递送生物聚合物和组织工程器械），它们的生物相容性和运输机制。DrugTarget Insights旨在为从事这一复杂，快速发展的领域的研究人员提供在线，开放的访问渠道。国际知名研究人员撰写的高度相关的学术文章。在文学不断发展的领域，研究人员越来越需要获得有关特定当代兴趣领域的最新，高质量的学术文章。本补充旨在通过提供高质量的文章来解决此问题，这些文章使读者可以区分信号与噪声。主编希望通过这项工作，可以帮助从业者和研究人员找到解决我们时代最复杂和紧迫问题的答案。迅速发展的人工修复和心血管疾病介入治疗的全景图需要对心血管疾病进行大量研究。开发具有最佳特性和性能的设备，以克服现有策略的缺点。在这种情况下，组织工程是一种有力的武器，可实现与宿主组织相互作用并影响其行为的复杂的生物相容性设备。能够感知生物环境并与之相互作用的“智能”生物材料的制造和设计是组织工程和再生医学的基石。这种发展已经摧毁了过时的手术原则，意味着用人造材料重建器官或器官的一部分。现代研究获得的更深刻理解凸显了异物在体内（尤其是在心血管系统中）长期共存的局限性以及生物学和临床缺陷。1需要尊重正常情况下发生的生理修复和重塑过程在自然界中，自然界在当前的研究中逐渐取得了重要的意义[2,3]，这表明有必要伴随着人体的生理反应和组织再生活动，而不是假装用“塑料”替代物代替它们。这种对组织工程中的再生生物学的关注以及对组织和细胞水平的微环境条件的关注在《药物靶点见解》的这一期特刊中得到了表达。在这种情况下，提出了有趣而复杂的方法，需要使用释放药物的药物递送装置以针对疾病或并发症的特定方面。在本期杂志中，Rapetto博士及其同事广泛回顾了庆大霉素浸润的胶原蛋白海绵（GICS）在预防胸骨伤口感染中的作用。这些输送装置的使用可将高浓度的抗生素局部输送到伤口，减少与庆大霉素毒性相关的并发症。4另一方面，替代使用能够释放抗凝剂（如肝素）的智能生物聚合物，以避免早期使用血管移植物血栓形成和衰竭将在《华尔街日报》的同一期杂志上发表和讨论。5正如本期其他论文所证明的那样，这些并不是该领域的唯一应用。确实，在实验水平上，已经进行了数项研究工作，以设计支架释放因子，药物或细胞因子，以改善组织再生或干细胞募集，或克服与假体相关的问题。6定制生物可吸收支架的可能性建立能够促进或引导组织再生的微环境是一个令人兴奋的研究领域。7,8此外，药物释放装置还可以避免或治疗与假体置换有关的某些缺点

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