Ethanol Extract of Stem Bark Show Remarkable Prophylactic Activity in Experimental –Infected Mice

Olayinka O Otegbade; Johnson A Ojo; Dolapo I Adefokun; Oyindamola O Abiodun; Bolaji N Thomas; Olusola Ojurongbe

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Ethanol Extract of Stem Bark Show Remarkable Prophylactic Activity in Experimental –Infected Mice

机译：茎皮乙醇提取物在实验感染小鼠中具有显着的预防活性

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This work explores the antiplasmodial potential of ethanol extract of Blighia sapida (Lin. Sapindaceae) in chloroquine (CQ)-resistant Plasmodium berghei (ANKA strain)–infected mice. Chloroquine-resistant (ANKA) strain of P berghei was inoculated intraperitoneally into Swiss albino mice. Mice were treated orally for 4 consecutive days, before and after inoculation (prophylactic, suppressive, and curative models) with graded doses of the plant extracts with Artemether-Lumefantrine (Coartem) as control. Prophylactically, the extract showed a remarkable activity in the chemosuppression of P berghei parasites (P?

机译：这项工作探讨了沙棘鱼（Lin。Sapindaceae）乙醇提取物在耐氯喹（CQ）的伯氏疟原虫（ANKA株）感染的小鼠中的抗疟原虫潜力。将伯氏疟原虫的耐氯喹（ANKA）株腹膜内接种到瑞士的白化病小鼠中。在接种之前和之后（预防性，抑制性和治愈性模型），对小鼠进行连续4天的口服治疗，其中以Artemether-Lumefantrine（复方蒿甲醚）为对照，采用分级剂量的植物提取物。预防性地，该提取物在200-800？mg / kg的剂量下对伯氏疟原虫的化学抑制作用表现出显着的活性（P？

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《Drug Target Insights》 |2017年第9期|共8页
作者
Olayinka O Otegbade; Johnson A Ojo; Dolapo I Adefokun; Oyindamola O Abiodun; Bolaji N Thomas; Olusola Ojurongbe;
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中图分类药学;
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2. Supressive and Prophylactic Potentials of Flavonoid-rich Extract of Adansonia digitata L. Stem Bark in Plasmodium berghei -infected Mice [J] . O. Adeoye Akinwunmi, C. Komolafe Kayode, D. Olatunde Moses Research journal of medicinal plant . 2016,第3期

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3. Antimalarial Effect of Combined Extracts of the Leaf of Ficus exasperata and Stem Bark of Anthocleista vogelii on Mice Experimentally Infected with Plasmodium berghei Berghei (Nk 65) [J] . Okpok Eta Okon, Lebari B. Gboeloh, Samuel Effiong Udoh Research journal of medicinal plant . 2014,第3期

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4. The Effect of Ethanol Extract of Noni (Leaves Morinda citrifolia) on Parasitemia in Balb/c Mice infected with Plasmodium berghei [C] . Jon Farizal, Leni Marlina, Susiwati International Conference on Inter-professional Health Collaboration . 2019

机译：Noni（叶Morinda citrifolia）对血浆/ C小鼠寄生虫血症患者乙醇提取物的影响Permodium Berghei
5. A comparison of both water and ethanol extracts prepared from Echinacea purpurea and Echinacea angustifolia on the response to Influenza A/PR/8/34 infection in mice. [D] . Singh, Navrozedeep. 2010

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6. Ethanol Extract of Blighia sapida Stem Bark Show Remarkable Prophylactic Activity in Experimental Plasmodium berghei–Infected Mice [O] . Olayinka O Otegbade, Johnson A Ojo, Dolapo I Adefokun, 2017

机译：番荔枝茎皮乙醇提取物在实验性伯氏疟原虫感染的小鼠中显示出显着的预防活性
7. Ethanol Extract of Stem Bark Show Remarkable Prophylactic Activity in Experimental –Infected Mice [O] . Olayinka O Otegbade, Johnson A Ojo, Dolapo I Adefokun, 2017

机译：茎秆的乙醇提取物在实验感染的小鼠中显示出显着的预防活性

Ethanol Extract of Stem Bark Show Remarkable Prophylactic Activity in Experimental –Infected Mice

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