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Bacopa monnieri, a Neuroprotective Lead in Alzheimer Disease: A Review on Its Properties, Mechanisms of Action, and Preclinical and Clinical Studies

机译： Bacopa monnieri ，阿尔茨海默氏病的神经保护先导：其性质，作用机理以及临床前和临床研究综述

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Alzheimer disease is a neurodegenerative disease that is signified by cognitive decline, memory loss, and erratic behavior. Till date, no cure for Alzheimer exists and the current Alzheimer medications have limited effectiveness. However, herbal medicines may slow down the disease’s progression, which may hopefully reduce the number of cases in the years to come. Numerous studies have been done on characterizing the neuroprotective properties from plants belonging to Scrophulariaceae family, particularly Bacopa monnieri and its polyphenolic compounds known as bacosides. This review presents the findings on bacosides in therapeutic plants and their impact on Alzheimer disease pathology. These reports present data on the clinical, cellular activities, phytochemistry, and biological applications that may be used in new drug treatment for Alzheimer disease.
机译：阿尔茨海默氏病是一种神经退行性疾病，表现为认知能力下降，记忆力减退和行为不稳定。直到现在，还没有治愈阿尔茨海默氏症的方法，目前的阿尔茨海默氏症药物疗效有限。但是，草药可能会减慢疾病的进程，从而有望在未来几年内减少病例数。已经进行了许多关于表征玄参科植物的神经保护特性的研究，特别是Bacopa monnieri及其多酚化合物称为椰油甙。这篇综述介绍了治疗性植物中椰油甙的发现及其对阿尔茨海默氏病病理的影响。这些报告提供了有关可用于阿尔茨海默氏病新药治疗的临床，细胞活性，植物化学和生物学应用的数据。

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