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Omalizumab as a Provoking Factor for Venous Thromboembolism

机译：奥马珠单抗是引起静脉血栓栓塞的诱因

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A 43-year-old man with a history of severe extrinsic allergic asthma treated with once-monthly omalizumab (600 mg) for the last 15 months. He presented to the emergency room with a 2-week history of right lower limb pain and chest pleuritic pain. Computed tomography pulmonary angiography showed bilateral pulmonary embolism with right-sided pulmonary infarction and ultrasound of right lower limb confirmed distal deep vein thrombosis. No other known risk factors were identified. Treatment with omalizumab was stopped during hospitalization. The Naranjo Adverse Drug Reaction (ADR) Probability Scale classifies this as a probable ADR (score of 6). Omalizumab is a humanized monoclonal anti-IgE antibody indicated for the treatment of persistent moderate-to-severe asthma and certain chronic refractory urticaria. The EXCELS study (The Epidemiologic Study of Xolair (omalizumab): Evaluating Clinical Effectiveness and Long-term Safety in Patients with Moderate-to-Severe Asthma), a postmarketing observational cohort study to assess clinical safety profile of omalizumab, showed a significant increase in venous thromboembolism. In conclusion, omalizumab has been associated with arterial and venous thromboembolic events, although the evidence is not definitive.
机译：一位有严重外源性过敏性哮喘病史的43岁男子，在过去15个月中每月接受一次奥马珠单抗（600毫克）治疗。他出现在急诊室，有2周的右下肢疼痛和胸膜胸膜炎病史。计算机断层扫描肺血管造影显示双侧肺栓塞伴右侧肺梗塞，右下肢超声检查证实远端深静脉血栓形成。没有发现其他已知的危险因素。住院期间停止使用奥马珠单抗治疗。 Naranjo药物不良反应（ADR）概率量表将其分类为可能的ADR（评分为6）。 Omalizumab是一种人源化单克隆抗IgE抗体，可用于治疗持续性中度至重度哮喘和某些慢性难治性荨麻疹。 EXCELS研究（Xolair（omalizumab）的流行病学研究：评估中度至重度哮喘患者的临床疗效和长期安全性）是一项上市后的观察性队列研究，旨在评估omalizumab的临床安全性，静脉血栓栓塞。总之，奥马珠单抗与动脉和静脉血栓栓塞事件有关，尽管证据尚不确定。

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