• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Drug Target Insights >Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions
【24h】

Modification of Monoaminergic Activity by MAO Inhibitors Influences Methamphetamine Actions

机译：MAO抑制剂对单胺能活性的修饰影响甲基苯丙胺的作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Methamphetamine (METH) abuse is a serious health and social problem worldwide. At present, however, there are no effective medications for the treatment of METH abuse. Of the intracellular METH target proteins, monoamine oxidase (MAO) is involved in the regulation of monoaminergic tone in the brain, resulting in the modulation of METHinduced behavioral abnormalities in mammals. The METH-induced expression of increased motor activity, stereotypy, and sensitization is closely associated with monoaminergic transmission in the brain. Modifi cation of MAO activity by MAO inhibitors can influence METH action. Of the MAO inhibitors, the propargylamine derivative clorgyline, an irreversible MAO-A inhibitor, effectively blocks METH-induced hyperlocomotion and behavioral sensitization in rodents. Analysis of the associated monoaminergic activity indicates an involvement of altered striatal serotonergic transmission as well as an increased dopaminergic tone. Some effects of MAO inhibitors on METH action appear to be independent of MAO, suggesting complex mechanisms of action of MAO inhibitors in METH abuse. This review describes current research to find effective treatment for METH abuse, using MAO inhibitors.
机译：甲基苯丙胺（METH）的滥用是全球范围内严重的健康和社会问题。但是，目前尚无有效的药物可用于治疗METH滥用。在细胞内METH靶蛋白中，单胺氧化酶（MAO）参与调节大脑中的单胺能基调，从而调节METH诱导的哺乳动物行为异常。 METH诱导的运动活动增加，刻板印象和致敏性表达与脑中单胺能传递密切相关。 MAO抑制剂对MAO活性的修饰可影响METH的作用。在MAO抑制剂中，炔丙基胺衍生物clorgyline是不可逆的MAO-A抑制剂，可有效阻断METH诱导的啮齿类动物的过度运动和行为敏化。相关单胺能活性的分析表明，纹状体5-羟色胺能传递的改变以及多巴胺能音调的增加都参与了。 MAO抑制剂对METH作用的某些作用似乎独立于MAO，这表明MAO抑制剂在METH滥用中的作用机理复杂。这篇综述描述了当前的研究，以寻找使用MAO抑制剂治疗METH滥用的有效方法。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号