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Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2

机译：重组人骨形态发生蛋白2促进成骨的作用

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Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation. To evaluate the effect of basic fibroblast growth factor (bFGF), FK506, elcatonin, and hyperbaric oxygenation (HBO) on osteoinduction by recombinant human bone morphogenetic protein-2 (rhBMP-2), 2 or 5 μg of rhBMP-2 was implanted into intramuscular sites of rats. At 21 days after implantation, the osteoinductive activity in the treatment group and control group was compared radiographically, biochemically, and histologically. The amount of new bone in the treatment group was signifi cantly greater than that in the control group. The alkaline phosphatase activity and calcium content in the treatment group were signifi cantly higher than those in the control group. These results suggest that bFGF, FK506, elcatonin, and HBO accelerated the activity and rate of osteoinduction by rhBMP2. These results may be useful when BMP is applied clinically in near future.
机译：骨形态发生蛋白（BMP）似乎是最有前途的细胞因子之一，可用于骨缺损和增生的重建手术中。为了评估碱性成纤维细胞生长因子（bFGF），FK506，降钙素和高压氧（HBO）对重组人骨形态发生蛋白2（rhBMP-2）骨诱导的影响，将2或5μgrhBMP-2植入大鼠的肌肉内部位。植入后第21天，通过射线照相，生化和组织学比较治疗组和对照组的骨诱导活性。治疗组的新骨量明显大于对照组。治疗组的碱性磷酸酶活性和钙含量明显高于对照组。这些结果表明bFGF，FK506，降钙素和HBO加速了rhBMP2的骨诱导活性和骨诱导率。当在不久的将来临床应用BMP时，这些结果可能有用。

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