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首页> 外文期刊>Drug Safety - Case Reports >Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension
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Secondary Raynaud’s Phenomenon and Skin Necrosis of Toes in the Paraplegic Patient with Hypertension

机译：截瘫性高血压患者继发性雷诺现象和脚趾皮肤坏死

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Abstract We present two cases of paraplegic patients who developed secondary Raynaud’s phenomenon. A 43-year-old man with paraplegia presented with dark purple discoloration and skin defects on his left second and third toes and complained of a cold sensation in both feet for a period of 1?year. He had been taking diuretics for 4?years. The capillary refilling time for both affected toes was delayed. His antihypertensive drug was changed to a calcium channel blocker under suspicion of Raynaud’s phenomenon aggravated by hydrochlorothiazide, and the capillary refilling time normalized within 3?days. The toe skin defect was covered with a skin graft. A 51-year-old man with paraplegia presented with cyanotic color change and recurrent unstable wounds on his toes. He was also taking diuretics for hypertension. Suspecting secondary Raynaud’s phenomenon aggravated by diuretics, we changed the diuretics to olmesartan medoxmil 20?mg and amlodipine besylate 2.5?mg per day. Subsequently, he has had no unstable wounds for 30?months. If hypertensive patients with paraplegia complain of skin discoloration in their extremities, Raynaud’s phenomenon should be considered and the antihypertensive drug may need to be stopped in order to improve the wound-healing process.
机译：摘要我们介绍了两例发生继发性雷诺现象的截瘫患者。一名患有截瘫的43岁男子，左脚第二和第三脚出现深紫色变色和皮肤缺陷，并抱怨双脚持续1年的冷感。他服用利尿剂已有4年了。两个受影响脚趾的毛细血管补充时间都被延迟。由于怀疑雷诺现象被氢氯噻嗪加重，他的降压药改为了钙通道阻滞剂，并且毛细血管补充时间在3天之内恢复正常。脚趾皮肤缺损被植皮覆盖。一名患有截瘫的51岁男子，脚色发，并出现反复不稳定的伤口。他还因高血压服用利尿剂。怀疑利尿剂加重继发性雷诺现象，我们将利尿剂改为每天使用20 mg的奥美沙坦medoxmil和2.5 mg的苯磺酸氨氯地平。随后，他已经有30个月没有不稳定的伤口了。如果患有截瘫的高血压患者抱怨其四肢出现皮肤变色，则应考虑雷诺现象，并可能需要停止使用降压药以改善伤口愈合过程。

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