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首页> 外文期刊>Japanese Journal of Pharmacology >Protective Effects of the Antianginal Agent Nicorandil on Arachidonate-Induced Sudden Death in Rats: Comparison with Several Antianginal Agents and Cyclooxygenase Inhibitors
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Protective Effects of the Antianginal Agent Nicorandil on Arachidonate-Induced Sudden Death in Rats: Comparison with Several Antianginal Agents and Cyclooxygenase Inhibitors

机译：抗心绞痛药尼古兰地对花生四烯酸酯诱导的大鼠猝死的保护作用：与几种抗心绞痛药和环氧合酶抑制剂的比较。

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References(18) Cited-By(1) In anesthetized rats, intra-carotid injections of arachidonate·Na (20 mg/kg) elicited a marked pressor response, producing death within 10 min in untreated rats. The antianginal agents (nicorandil, nitroglycerin and diltiazem) and cyclooxygenase inhibitors (indomethacin and aspirin), applied i.v. or p.o., effectively protected the rats from death. In the surviving rats, these drugs significantly prevented intravascular thrombosis in cerebral vessels and the marked pressor response to arachidonate·Na. The protective mechanism of the antianginal agents tested seems to be different from that of cyclooxygenase inhibitors.
机译：参考文献（18）被引用（1）在麻醉的大鼠中，颈动脉内注射花生四烯酸·钠（20 mg / kg）引起明显的升压反应，在未经治疗的大鼠中在10分钟内死亡。抗心绞痛药（尼可地尔，硝酸甘油和地尔硫卓）和环氧合酶抑制剂（吲哚美辛和阿司匹林）在静脉内应用。或p.o.，有效地保护了老鼠免于死亡。在幸存的大鼠中，这些药物显着预防了脑血管的血管内血栓形成和对花生四烯酸·Na的明显升压反应。测试的抗心绞痛药的保护机制似乎与环氧合酶抑制剂的保护机制不同。

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