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首页> 外文期刊>Japanese Journal of Pharmacology >Possible Involvement of Nitric Oxide in Acetylcholine-Induced Increase of Intracellular Ca2+ Concentration and Catecholamine Release in Bovine Adrenal Chromaffin Cells
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Possible Involvement of Nitric Oxide in Acetylcholine-Induced Increase of Intracellular Ca2+ Concentration and Catecholamine Release in Bovine Adrenal Chromaffin Cells

机译：一氧化氮可能参与乙酰胆碱诱导的牛肾上腺嗜铬细胞中细胞内Ca2 +浓度和儿茶酚胺释放的增加

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References(15) Cited-By(27) The role of nitric oxide (NO) in neurotransmitter release was studied using bovine adrenal medullary chromaffin cells. L-Arginine and sodium nitroprusside (SNP) slightly increased the intracellular free calcium concentration ([Ca2+]i), and the effects of the agents were dependent on the presence of the extracellular Ca2+ ([Ca2+]o), but were not blocked by verapamil (30 μM) or diltiazem (30 μM). SNP enhanced the acetylcholine (ACh)-induced rise in [Ca2+]i in the presence but not in the absence of [Ca2+]o. The effects of L-arginine but not those of SNP were inhibited by Nω-nitro-L-arginine (L-NNA). L-NNA significantly reduced the ACh-induced rise in [Ca2+]i and catecholamine (CA) release, and the reduction was restored by L-arginine but not by D-arginine. These results suggest a possible involvement of NO in ACh-induced [Ca2+]i rise and CA release in bovine adrenal chromaffin cells.
机译：参考文献（15）被引用的文献（27）使用牛肾上腺髓质嗜铬细胞研究了一氧化氮（NO）在神经递质释放中的作用。 L-精氨酸和硝普钠（SNP）略微增加了细胞内游离钙的浓度（[Ca2 +] i），这些药物的作用取决于细胞外Ca2 +（[Ca2 +] o）的存在，但并未被维拉帕米（30μM）或地尔硫卓（30μM）。在存在[Ca2 +] o的情况下，SNP增强了乙酰胆碱（ACh）诱导的[Ca2 +] i的升高，但在没有[Ca2 +] o的情况下没有。 Nω-硝基-L-精氨酸（L-NNA）抑制L-精氨酸的作用而不抑制SNP的作用。 L-NNA显着降低了ACh诱导的[Ca2 +] i和儿茶酚胺（CA）释放的增加，并且L-精氨酸可恢复该下降，而D-精氨酸则不能恢复。这些结果表明，NO可能参与了牛肾上腺嗜铬细胞中ACh诱导的[Ca2 +] i升高和CA释放。

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