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首页> 外文期刊>Japanese Journal of Pharmacology >Involvement of γ-Aminobutyric Acid (GABA) B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats
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Involvement of γ-Aminobutyric Acid (GABA) B Receptors in the Hypotensive Effect of Systemically Administered GABA in Spontaneously Hypertensive Rats

机译：γ-氨基丁酸（GABA）B受体参与自发性高血压大鼠全身施用GABA的降压作用

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References(33) Cited-By(23) We investigated the effects of intraduodenally (i.d.) administered γ-aminobutyric acid (GABA) on blood pressure (BP) in anesthetized spontaneously hypertensive rats (SHR) and the mechanism underlying this effect, especially the type of GABA receptor involved in the depressive effect of this amino acid. GABA (0.3 to 300 mg/kg, i.d.) caused a dose-related decrease in the BP of 9.20 ± 3.96 to 35.0 ± 5.34 mmHg (mean ± S.E.M.) that lasted for 30 to 50 min. The minimum effective i.d. dose of GABA was 0.3 to 1.0 mg/kg. Results pertaining to the mechanism underlying the GABA-induced effects on BP were as follows: a) GABA did not alter the BP-related effects of exogenous noradrenaline and acetylcholine; b) pretreatment with hexamethonium decreased the GABA-induced fall in BP, and GABA tended to reduce the pressor response associated with injection of dimethyl phenylpiperazinium; and c) pretreatment with 2-hydroxysaclofen markedly reduced the GABA-induced drop in BP, whereas pretreatment with bicuculline did not. In conclusion, in SHR, low-dose (0.3 to 1.0 mg/kg, i.d.) GABA had a hypotensive effect, which may result from attenuation of sympathetic transmission through the activation of GABAB receptors at presynaptic or ganglionic sites.
机译：参考文献（33）Cited-By（23）我们研究了十二指肠内（id）施用γ-氨基丁酸（GABA）对麻醉的自发性高血压大鼠（SHR）血压（BP）的影响以及这种作用的机制，特别是这种氨基酸的抑制作用涉及的GABA受体类型。 GABA（0.3至300 mg / kg，i.d.）导致与剂量相关的BP降低9.20±3.96至35.0±5.34 mmHg（平均±S.E.M.），持续30至50分钟。最小有效内径GABA的剂量为0.3至1.0mg / kg。与GABA诱导的BP作用有关的机制有关的结果如下：a）GABA不会改变外源性去甲肾上腺素和乙酰胆碱的BP相关作用; b）六甲铵预处理减少了GABA引起的BP下降，并且GABA倾向于减少与注射二甲基苯基哌嗪有关的升压反应; c）用2-羟基沙氯芬预处理可明显降低GABA诱导的BP下降，而用双小分子预处理则不能。总之，在SHR中，低剂量（0.3至1.0 mg / kg，即日）的GABA具有降压作用，这可能是由于突触前或神经节部位GABAB受体的活化减弱了交感神经传递所致。

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