首页> 外文期刊>Japanese Journal of Pharmacology >KCl-Depolarization Potentiates the Ca2+ Sensitization by Endothelin-1 in Canine Coronary Artery
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KCl-Depolarization Potentiates the Ca2+ Sensitization by Endothelin-1 in Canine Coronary Artery

机译:KCl去极化增强内皮素-1在犬冠状动脉中的Ca2 +增敏作用。

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References(10) Cited-By(8) In Ca2+-free solution containing endothelin-1 (ET-1), depolarization by high KCl increased the force of contraction without any changes in intracellular calcium concentration ([Ca2+]i) in canine coronary artery. The [Ca2+]i-force relationships were examined in the absence or presence of ET-1 in 5 or 90 mM KCl. The relation curve in the presence of ET-1 in 90 mM KCl-PSS was shifted to the left and upward compared with that in 5 mM KCl. These results suggest that KCl-depolarization potentiates the Ca2+ sensitization by ET-1.
机译:参考文献(10)被引用(8)在含有内皮素-1(ET-1)的无Ca2 +的溶液中,高KCl的去极化作用增加了收缩力,而犬冠状动脉的细胞内钙浓度([Ca2 +] i)没有任何变化动脉。在不存在或存在5或90 mM KCl的ET-1的情况下检查[Ca2 +] i力关系。与5mM KCl相比,在90 mM KCl-PSS中存在ET-1时的关系曲线向左和向上移动。这些结果表明,KCl去极化增强了ET-1对Ca2 +的致敏作用。

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