Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion

Kazuhiko Kubota; Kiminobu Sugaya; Masanori Takahashi

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Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion

机译：胆囊收缩素保护胆碱能神经元免受基底前脑病变的侵害

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References(15) Cited-By(9) Alzheimer''s Disease (AD) patients have a severe degeneration of cholinergic neurons in their cerebral cortices. Basal forebrain (BF)-lesioned rat is used as a model animal of a cholinergic deficit in the cerebral cortex. Cholinergic markers were decreased in the cerebral cortex of BF-lesioned rats. Intracerebroventricular continuous infusion of cholecystokinin octapeptide (CCK8) following BF lesion obviously preserved these cholinergic markers. These results suggest that CCK8 prevents the degeneration of cholinergic neurons in the cerebral cortex following BF lesion.

机译：参考文献（15）（9）被引用的阿尔茨海默氏病（AD）患者的大脑皮层中胆碱能神经元严重变性。基底前脑（BF）损伤的大鼠被用作大脑皮质胆碱能缺乏的模型动物。 BF损伤大鼠的大脑皮层胆碱能标记降低。 BF病变后脑室内连续输注胆囊收缩素八肽（CCK8）明显保留了这些胆碱能标志物。这些结果表明，CCK8可防止BF病变后大脑皮层中胆碱能神经元的变性。

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《Japanese Journal of Pharmacology》 |1992年第1期|共页
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Kazuhiko Kubota; Kiminobu Sugaya; Masanori Takahashi;
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1. Minocycline protects basal forebrain cholinergic neurons from mu p75-saporin immunotoxic lesioning. [J] . Hunter CL, Quintero EM, Gilstrap L, The European Journal of Neuroscience . 2004,第12期

机译：米诺环素可保护基底前脑胆碱能神经元免受mu p75-saporin免疫毒性损害。
2. Cholecystokinin-8 protects central cholinergic neurons against fimbria-fornix lesion through the up-regulation of nerve growth factor synthesis [J] . PAOLA TIRASSA, CARINA STENFORS Proceedings of the National Academy of Sciences of the United States of America . 1999,第11期

机译：胆囊收缩素8通过上调神经生长因子的合成保护中枢胆碱能神经元免受菌丝-穹ni皮病变
3. SUT-8701, a Cholecystokinin Analog, Prevents the Cholinergic Degeneration in the Rat Cerebral Cortex Following Basal Forebrain Lesioning [J] . Kazuhiko Kubota, Kiminobu Sugaya, Kumi Kojima, Japanese Journal of Pharmacology . 1993,第4期

机译：SUT-8701，一种胆囊收缩素类似物，可防止基底前脑损伤后大鼠大脑皮层的胆碱能变性
4. Spiking neuron model of basal forebrain enhancement of visual attention [C] . Avery Michael, Krichmar Jeffrey L., Dutt Nikil Neural Networks (IJCNN), The 2012 International Joint Conference on . 2012

机译：基底前脑刺突神经元模型增强视觉注意
5. Factors influencing function: Activation of antigen presenting cells by the cholera toxin B-subunit, and regulation of the cholinergic phenotype in nerve growth factor receptor-positive basal forebrain cholinergic neurons by bone morphogenetic protein 9. [D] . Schnitzler, Aletta Christina. 2007

机译：影响功能的因素：霍乱毒素B亚基激活抗原呈递细胞，并通过骨形态发生蛋白9调节神经生长因子受体阳性基底前脑胆碱能神经元的胆碱能表型。
6. Cholecystokinin-8 protects central cholinergic neurons against fimbria–fornix lesion through the up-regulation of nerve growth factor synthesis [O] . Paola Tirassa, Luigi Aloe, Carina Stenfors, 1999

机译：胆囊收缩素8通过上调神经生长因子的合成来保护中枢胆碱能神经元免受纤维-穹for皮病变
7. Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion [O] . Kiminobu Sugaya, Masanori Takahashi, Kazuhiko Kubota 1992

机译：Cholecystokinin保护胆碱能神经元免受基础前脑病变

Cholecystokinin Protects Cholinergic Neurons against Basal Forebrain Lesion

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