Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice

Kimiko Tsutsumi; Rui-Hai Zhou; Shigeyuki Nakano

首页> 外文期刊>Japanese Journal of Pharmacology >Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice

【24h】

Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice

机译：隔离住房和给药时间对小鼠茶碱动力学的影响

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

References(15) ICR mice were grouped according to 1) housing environment: individual (I) or aggregated (A) and 2) timing of drug administration: midlight (L) or middark (D), i.e. I-L, I-D, A-L, A-D groups. Theophylline was orally administered at midlight or middark. The results showed that both social environment and timing of drug administration exerted significant influence on the pharmacokinetics of theophylline. These data may suggest the importance of considering many non-drug factors in toxicological studies with experimental animals.

机译：参考文献（15）将ICR小鼠按以下条件分组：1）居住环境：个人（I）或集合（A）; 2）给药时间：中光（L）或中暗（D），即IL，ID，AL，AD组。茶碱在中午或中午口服。结果表明，社会环境和给药时间均对茶碱的药代动力学有重要影响。这些数据可能表明在对实验动物进行毒理学研究时考虑许多非药物因素的重要性。

著录项

来源
《Japanese Journal of Pharmacology》 |1992年第3期|共3页
作者
Kimiko Tsutsumi; Rui-Hai Zhou; Shigeyuki Nakano;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类药理学;
关键词

相似文献

外文文献
中文文献
专利

1. Effects of isolation housing and timing of drug administration on amikacin kinetics in mice [J] . ZHOU Rui-Hai, TSUTSUMI Kimiko, NAKANO Shigeyuki Acta Pharmacologica Sinica . 1997,第4期

机译：隔离室和给药时间对小鼠丁胺卡那霉素动力学的影响
2. Effects of water deprivation on the pharmacokinetics of theophylline and one of its metabolites, 1,3-dimethyluric acid, after intravenous and oral administration of aminophylline to rats. [J] . Choi HD, Kang HE, Chung HJ, Biopharmaceutics and Drug Disposition . 2007,第8期

机译：在大鼠静脉内和口服给予氨茶碱后，缺水对茶碱及其代谢物之一1,3-二甲基尿酸的药代动力学的影响。
3. The effects of concomitant administration of theophylline and toborinone on the pharmacokinetics of both compounds in poor and extensive metabolizers via CYP2D6. [J] . Tammara B, Trang JM, Miyamoto G, The Journal of Clinical Pharmacology: Official Journal of the American College of Clinical Pharmacology . 2002,第5期

机译：通过CYP2D6同时给予茶碱和托邦酮对弱代谢者和广泛代谢者中两种化合物的药代动力学的影响。
4. Study of the drug release kinetics in nanoscale micelle to micelle system [C] . Wang Hong, Hongyu Chen Nanoelectronics Conference (INEC), 2010 . 2010

机译：纳米胶束对胶束系统的释药动力学研究
5. Micelle-forming macromolecular conjugates of methotrexate and paclitaxel: Structural effects on micellar properties and drug release. [D] . Li, Yu. 2000

机译：甲氨蝶呤和紫杉醇的胶束形成大分子共轭物：对胶束特性和药物释放的结构影响。
6. Reversal of the Detrimental Effects of Post-Stroke Social Isolation by Pair-Housing is Mediated by Activation of BDNF-MAPK/ERK in Aged Mice [O] . Rajkumar Verma, Nia M. Harris, Brett D. Friedler, -1

机译：BDNF-MAPK / ERK在衰老小鼠中的激活介导了成对的中风后社会隔离对有害影响的逆转。
7. Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice. [O] . Rui-Hai Zhou, Kimiko Tsutsumi, Shigeyuki Nakano 1992

机译：分离外壳和药物施用时间对小鼠茶碱动力学的影响。
8. Pharmacokinetics and Immunologic Consequences of Repeated Administrations of Purified Butyrylcholinesterases in Mice [R] . Sun, W. , Naik, R. S. , Luo, C. , 2004

机译：重复给药纯化丁酰胆碱酯酶在小鼠体内的药代动力学和免疫学后果

Effects of Isolation Housing and Timing of Drug Administration on Theophylline Kinetics in Mice

摘要

著录项

相似文献

相关主题

期刊订阅