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首页> 外文期刊>Japanese Journal of Pharmacology >Relationship between Density of Muscarinic Receptors and Nasal Hypersecretion in a Nasal Allergic Model
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Relationship between Density of Muscarinic Receptors and Nasal Hypersecretion in a Nasal Allergic Model

机译：鼻过敏模型中毒蕈碱受体密度与鼻分泌过多的关系

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References(26) Cited-By(1) In guinea pigs actively sensitized with ovalbumin, we have observed that nasal hyper-reactivity and hypersensitivity to methacholine causes nasal secretion accompanied by an increase in the density of muscarinic acetylcholine receptor (m-ACh·R) following the appearance of nasal symptoms induced by the ovalbumin challenge. Therefore in the present investigation, we studied the relationship between the density of m-ACh·R and nasal hypersecretion in actively sensitized guinea pigs. There was no relationship between the quantity of nasal secretion and serum IgG1 or IgE levels. On the other hand, the sensitivity to methacholine and nasal secretion induced by methacholine were significantly related to the density of m-ACh·R located on the nasal mucosa. The quantity of nasal secretion induced by allergen was also correlated significantly to the density of m-ACh·R. These results suggest that the nasal hypersecretion observed in the nasal allergic model may be closely associated with an increase in the density of m-ACh·R located on the nasal mucosa.
机译：参考文献（26）被引用的By（1）在对卵清蛋白积极致敏的豚鼠中，我们观察到鼻腔对甲甲胆碱的过度反应和超敏反应会导致鼻分泌，同时毒蕈碱型乙酰胆碱受体（m-ACh·R ）卵白蛋白激发引起的鼻部症状出现。因此，在本研究中，我们研究了主动致敏豚鼠的m-ACh·R密度与鼻腔分泌过多之间的关系。鼻分泌量与血清IgG1或IgE水平无关。另一方面，乙酰甲胆碱对乙酰甲胆碱和鼻分泌物的敏感性与位于鼻粘膜上的m-ACh·R的密度显着相关。过敏原诱导的鼻分泌量也与m-ACh·R的密度显着相关。这些结果表明，在鼻过敏模型中观察到的鼻分泌过多可能与位于鼻粘膜上的m-ACh·R的密度增加密切相关。

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