• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Japanese Journal of Pharmacology >Stimulation by Capsaicin of Gastric Alkaline Secretion in Anesthetized Rats
【24h】

Stimulation by Capsaicin of Gastric Alkaline Secretion in Anesthetized Rats

机译：辣椒素对麻醉大鼠胃碱性分泌物的刺激作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

References(22) Cited-By(1) Effects of mucosal application of capsaicin on alkaline secretion were examined in the stomachs of anesthetized rats and compared with those in the duodenum. The stomach (acid secretion was inhibited by omeprazole given i.p.) or the duodenum was perfused with saline (pH 4.5); both the pH of the perfusate and transmucosal potential difference (PD) were continuously monitored; and the HCO3- output was determined by the pH change. Under these conditions, the mucosal application of capsaicin (0.3-6 mg/ml for 30 min) caused significantly increased pH and HCO3- output in a concentration-related manner in both tissues, while PD increased in the duodenum and decreased in the stomach. The HCO3- stimulatory action of capsaicin was markedly attenuated by sensory deafferentation, significantly mitigated by prior administration of indomethacin, and exhibited a marked tachyphylaxis after the repeated exposure at a high concentration (6 mg/ml). None of these treatments had any effect on the pH, PD and HCO3- responses induced by prostaglandin E2 (300 μg/kg, i.v.) in these tissues. These results indicate that mucosal application of capsaicin increased the gastroduodenal HCO3- output by stimulation of capsaicin-sensitive sensory neurons. This action may be in part mediated by endogenous prostaglandins.
机译：参考文献（22）引用了（1）在麻醉大鼠的胃中检查了辣椒碱黏膜施用对辣椒碱分泌的影响，并与十二指肠中的进行了比较。胃（腹腔注射奥美拉唑抑制酸分泌）或十二指肠灌注生理盐水（pH 4.5）;连续监测灌注液的pH值和跨粘膜电位差（PD）。 HCO3的产量由pH的变化决定。在这些条件下，辣椒素的粘膜应用（0.3-6 mg / ml持续30分钟）导致两种组织中的pH和HCO3-的输出以浓度相关的方式显着增加，而十二指肠中的PD增加而胃中的PD减少。辣椒素的HCO3-刺激作用被感觉上的脱除咖啡因作用明显减弱，事先给予消炎痛的作用明显减轻，并且在高浓度（6 mg / ml）的重复暴露后表现出明显的速激肽抑制作用。这些治疗均未对这些组织中前列腺素E2（300μg/ kg，i.v.）诱导的pH，PD和HCO3-反应产生任何影响。这些结果表明，通过刺激辣椒素敏感的感觉神经元，粘膜施用辣椒素增加了胃十二指肠HCO3-的输出。该作用可能部分地由内源性前列腺素介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号