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首页> 外文期刊>Japanese Journal of Pharmacology >Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats
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Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats

机译：川methyl嗪改善大鼠永久性双侧颈总动脉或东pol碱的闭塞所致的空间认知障碍

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References(24) Cited-By(18) Effects of tetramethylpyrazine (TMP), a major constituent of Ligusticum chuanxiong, on spatial cognitive impairment induced by permanent occlusion of bilateral common carotid arteries (2VO) and scopolamine were investigated using 8-arm radial maze performance in rats. Permanent 2VO produced a severe learning deficit in non-pretrained rats. Daily administration of TMP (3 -10 mg/kg, i.p.) from the 3rd day after permanent 2VO significantly improved the learning deficit. TMP did not influence the impairment of the retention task in the pretrained permanent 2VO rats, but it tended to reduce the number of errors elevated by 3-min delay interposition in these rats. In the scopolamine model, scopolamine (0.3 mg/kg, i.p.) significantly decreased the initial correct response and increased the number of errors. Single administration of TMP (1-3 mg/kg, i.p.) dose-dependently reversed the scopolamine-induced impairment of the maze performance. These results suggest that TMP has therapeutic potential for the treatment of dementia caused by cholinergic dysfunction and/or decrease of cerebral blood flow.
机译：参考文献（24）（8）用八臂radial骨迷宫研究川Li的主要成分四甲基吡嗪（TMP）对双侧颈总动脉（2VO）和东碱的永久性咬合引起的空间认知障碍的影响。在大鼠中的表现。永久2VO在未训练的大鼠中产生严重的学习缺陷。永久性2VO后第3天每天服用TMP（3 -10 mg / kg，腹腔注射）可显着改善学习障碍。在预训练的永久性2VO大鼠中，TMP不会影响保留任务的损伤，但会减少这些大鼠中因3分钟延迟插入而增加的错误数。在东pol碱模型中，东pol碱（0.3 mg / kg，i.p.）显着降低了最初的正确反应并增加了错误数量。单次服用TMP（1-3 mg / kg，腹腔注射）剂量依赖性地逆转了东pol碱引起的迷宫性能损害。这些结果表明，TMP具有治疗胆碱能功能障碍和/或脑血流减少引起的痴呆的治疗潜力。

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