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首页> 外文期刊>Japanese Journal of Pharmacology >Importance of Impairment of the Airway Epithelium for Ozone-Induced Airway Hyperresponsiveness in Guinea Pigs
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Importance of Impairment of the Airway Epithelium for Ozone-Induced Airway Hyperresponsiveness in Guinea Pigs

机译：豚鼠臭氧诱导的气道高反应性的气道上皮受损的重要性

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References(31) Cited-By(8) We examined the relationship between ozone (O3)-induced airway hyperresponsiveness (AHR) and inflammation in guinea pigs. Inhalation of methacholine (MCh) was adopted in the time course study of AHR that was assessed by measuring pulmonary inflation pressure after O3 exposure (3 ppm, for 2 hr) because the degree of AHR detected by inhalation of MCh was greater than that detected by i.v. administration. AHR was detected up to 5 hr after O3 exposure and was not observed at 24 and 48 hr. In the bronchoalveolar lavage (BAL) study, the numbers of neutrophils, eosinophils, lymphocytes and macrophages in BAL fluid (BALF) reached maximum at 24 hr or later. On the other hand, the number of airway epithelial cells in the BALF significantly increased at 2 and 5 hr. In the histological study, disorder and impairment of the airway epithelium in the trachea and lung were observed at 2 and 5 hr. Changes in the airway epithelium were recovered at 48 hr, although an increase in leukocytes was observed in the lung. These results indicate that O3-induced AHR in guinea pigs is most probably associated with impairment of the epithelium rather than with infiltration of inflammatory cells in the airway.
机译：参考文献（31）（8）我们研究了臭氧（O3）诱导的豚鼠气道高反应性（AHR）与炎症之间的关系。在AHR的时程研究中采用了甲胆碱（MCh）吸入法，该研究通过测量O3暴露（3 ppm，持续2小时）后的肺膨胀压来进行评估，因为通过吸入MCh所检测到的AHR程度要高于通过MCh检测到的AHR程度。 iv行政。在O3暴露后最多5小时检测到AHR，而在24和48小时未观察到AHR。在支气管肺泡灌洗（BAL）研究中，BAL液（BALF）中的中性粒细胞，嗜酸性粒细胞，淋巴细胞和巨噬细胞的数量在24小时或更晚时达到最大值。另一方面，BALF中气道上皮细胞的数量在2和5小时显着增加。在组织学研究中，在2和5小时观察到气管和肺中的气道上皮紊乱和受损。尽管在肺中观察到白细胞增加，但气道上皮的变化在48小时恢复。这些结果表明，O3诱导的豚鼠AHR最有可能与上皮受损有关，而不是与气道中炎性细胞的浸润有关。

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