• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Japanese Journal of Pharmacology >Inhibitory Effect of KBT-3022, a New Anti-platelet Agent, on Infiltration of Polymorphonuclear Leukocytes Induced by Leukotriene B4 or Formyl-Methionyl-Leucyl-Phenylalanine in Mice
【24h】

Inhibitory Effect of KBT-3022, a New Anti-platelet Agent, on Infiltration of Polymorphonuclear Leukocytes Induced by Leukotriene B4 or Formyl-Methionyl-Leucyl-Phenylalanine in Mice

机译：新型抗血小板药KBT-3022对白三烯B4或甲酰基-甲硫基-亮氨酰-苯丙氨酸诱导的多形核白细胞浸润的抑制作用

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

References(15) Cited-By(1) We devised a method for evaluating polymorphonuclear leukocyte (PMN) infiltration in vivo employing an air bleb technique combined with measurement of myeloperoxidase (MPO) activity, and the effects of some anti-platelet agents were evaluated. KBT-3022 (ethyl 2-[4, 5-bis(4-methoxyphenyl)thiazol-2-yl]pyrrol-1-ylacetate) and cilostazol inhibited the increase in MPO activity in the connective tissue around the air bleb induced by leukotriene B4 (LTB4) and formyl-methionyl-leucyl-phenylalanine (fMLP). Indomethacin inhibited only the fMLP-induced increase in MPO activity, but ticlopidine hydrochloride and acetylsalicylic acid had no effect. Histologic observation confirmed the inhibition of PMN infiltration by KBT-3022. These results indicate that KBT-3022 may be a potent inhibitor of both LTB4- and fMLPinduced infiltration of PMNs.
机译：参考文献（15）被引用者（1）我们设计了一种方法，该方法使用空气泡技术结合测量髓过氧化物酶（MPO）活性来评估体内多形核白细胞（PMN）的浸润，并评估了某些抗血小板药的作用。 KBT-3022（2- [4,5-双（4-甲氧基苯基）噻唑-2-基]吡咯-1-基乙酸乙酯）和西洛他唑抑制白三烯B4诱导的气泡周围结缔组织中MPO活性的增加（LTB4）和甲酰基-甲硫酰基-亮氨酰-苯丙氨酸（fMLP）。消炎痛仅抑制fMLP诱导的MPO活性增加，但盐酸噻氯匹定和乙酰水杨酸则无作用。组织学观察证实KBT-3022抑制了PMN的浸润。这些结果表明KBT-3022可能是LTB4-和fMLP诱导的PMN浸润的有效抑制剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号