Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices

Akemichi Baba; Hiroshi Saga; Hitoshi Hashimoto; Jun-ichi Kitanaka; Kaoru Kondo; Kazuko Sakata

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Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices

机译：谷氨酸减轻大鼠脑切片中垂体腺苷酸环化酶激活多肽对环AMP的刺激作用。

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References(13) Cited-By(1) In rat hippocampal slices, pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) stimulated cyclic AMP formation in dose- and time-dependent manners. The PACAP-38 action was dose-dependently attenuated by L-glutamate in the hippocampus; L-glutamate at the concentration of 1 mM attenuated PACAP-38-stimulated cyclic AMP formation by approximately 30%. The inhibitory effect of L-glutamate is also observed in rat cerebellar slices. In contrast, the inhibitory effect of a prostanoid EP3- receptor agonist on PACAP-38-stimulated cyclic AMP formation was brain region-specific; the inhibitory action was observed in the cerebellum but not in the hippocampus.

机译：参考文献（13）引用（1）在大鼠海马切片中，垂体腺苷酸环化酶激活多肽38（PACAP-38）以剂量和时间依赖性方式刺激了环AMP的形成。海马中的L-谷氨酸盐可剂量依赖性地减弱PACAP-38的作用。浓度为1 mM的L-谷氨酸使PACAP-38刺激的环AMP的形成减少了约30％。在大鼠小脑切片中也观察到了L-谷氨酸的抑制作用。相反，前列腺素EP3-受体激动剂对PACAP-38刺激的环AMP形成的抑制作用是脑区域特异性的。在小脑中观察到抑制作用，但在海马中未观察到抑制作用。

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《Japanese Journal of Pharmacology》 |1995年第4期|共3页
作者
Akemichi Baba; Hiroshi Saga; Hitoshi Hashimoto; Jun-ichi Kitanaka; Kaoru Kondo; Kazuko Sakata;
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1. Pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal peptide-stimulated cyclic AMP synthesis in rat cerebral cortical slices: interaction with noradrenaline, adrenaline, and forskolin. [J] . Nowak JZ, mina1.zabpan.lodz.pl, Kuba K Journal of Molecular Neuroscience: MN . 2002,第1a2期

机译：大鼠脑皮质切片中垂体腺苷酸环化酶激活多肽和血管活性肠肽刺激的环AMP合成：与去甲肾上腺素，肾上腺素和毛喉素的相互作用。
2. Effect of glucocorticoid dexamethasone on cyclic AMP formation stimulated by pituitary adenylate cyclase-activating polypeptide (PACAP) in the cerebral cortex and hypothalamus of chick. [J] . Jolanta B. Zawilska, Jerzy Z. Nowak Pharmacological reports: PR . 2001,第1期

机译：糖皮质激素地塞米松对雏鸡大脑皮质和下丘脑垂体腺苷酸环化酶激活多肽（PACAP）刺激的环AMP形成的影响。
3. Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptides stimulate mitogen-activated protein kinase in the pituitary cell line GH4C1 by a 3',5'-cyclic adenosine monophosphate pathway. [J] . Le Pechon-Vallee-C, Magalon K, Rasolonjanahary R, Neuroendocrinology: International Journal for Basic and Clinical Studies on Neuroendocrine Relationships . 2000,第1期

机译：血管活性肠多肽和垂体腺苷酸环化酶激活多肽通过3'，5'-环腺苷一磷酸途径刺激垂体细胞系GH4C1中的促分裂原活化蛋白激酶。
4. Effects of Pituitary Adenylate Cyclase-Activating Polypeptide, Vasoactive Intestinal Polypeptide, and Somatostatin on the Release of Thyrotropin from the Bullfrog Pituitary [C] . REIKO OKADA, KAZUTOSHI YAMAMOTO, YOICHI ITO, International Symposium on VIP, PACAP, and Related Peptides . 2006

机译：垂体腺苷酸环酶激活多肽，血管活性肠多肽和生长抑素对牛蛙垂体脱毛素释放的影响
5. Hypothalamic pituitary adenylate cyclase-activating polypeptide: Impact on energy homeostasis and glutamate signaling. [D] . Resch, Jon Michael. 2014

机译：下丘脑垂体腺苷酸环化酶激活多肽：对能量稳态和谷氨酸信号的影响。
6. Correction: Lot1 is a key element of the pituitary adenylate cyclase-activating polypeptide (PACAP)/cyclic AMP pathway that negatively regulates neuronal precursor proliferation. [O] . Tatiana Fila, Stefania Trazzi, Christophe Crochemore, 2020

机译：校正：Lot1是垂体腺苷酸环化酶激活多肽（PACAP）/环状AMP通路的关键元素它负调控神经元前体的增殖。
7. Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices [O] . Kaoru Kondo, Hitoshi Hashimoto, Kazuko Sakata, 1995

机译：垂体腺苷酸环酶激活多肽的循环AMP形成的刺激通过谷氨酸在大鼠脑切片中衰减

Stimulation of Cyclic AMP Formation by Pituitary Adenylate Cyclase-Activating Polypeptide Is Attenuated by Glutamate in Rat Brain Slices

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