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首页> 外文期刊>Japanese Journal of Pharmacology >Insulin-like Action of Chromate on Glucose Transport in Isolated Rat Adipocytes
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Insulin-like Action of Chromate on Glucose Transport in Isolated Rat Adipocytes

机译：铬酸盐的胰岛素样作用对离体大鼠脂肪细胞葡萄糖转运的作用

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References(22) Cited-By(7) The effects of chromium compounds on 3-O-methylglucose (3-O-MG) transport were studied in isolated rat adipocytes. Sodium chromate significantly stimulated 3-O-MG uptake into adipocytes in a dose-dependent manner without altering the equilibrium space of 3-O-MG in adipocytes. The stimulatory effect reached the maximum at 300 μM, and the effect was 60-70% of the maximal insulin effect that was obtained with 20 nM insulin. The chromate concentration achieving a half-maximal effect was estimated at 50 μM. The effect of the combination of 1 mM chromate and 20 nM insulin was equipotent to that of 20 nM insulin alone, which showed that these two effects were not additive. The stimulatory effects of 1 mM chromate and 20 nM insulin were entirely abolished in adipocytes deprived of ATP, which indicated that these effects were completely ATP-dependent. Judging from experiments using various chromium compounds, CrO42- was responsible for the insulinomimetic action. These results indicate that the action of CrO42- is exerted through a mechanism analogous to that of insulin action, and that CrO42- is a novel and useful tool for studying issues involved in insulin actions.
机译：参考文献（22）引用了（7）在分离的大鼠脂肪细胞中研究了铬化合物对3-O-甲基葡萄糖（3-O-MG）转运的影响。铬酸钠以剂量依赖的方式显着刺激3-O-MG摄入脂肪细胞，而不会改变脂肪细胞中3-O-MG的平衡空间。刺激作用在300μM处达到最大，其作用是20 nM胰岛素所产生的最大胰岛素作用的60-70％。达到一半效果的铬酸盐浓度估计为50μM。 1 mM铬酸盐和20 nM胰岛素联合使用的效果与单独使用20 nM胰岛素的效果相同，这表明这两种效果不是累加的。在不含ATP的脂肪细胞中，完全消除了1 mM铬酸盐和20 nM胰岛素的刺激作用，这表明这些作用完全依赖于ATP。从使用各种铬化合物的实验来看，CrO42-负责胰岛素模拟作用。这些结果表明，CrO42-的作用是通过类似于胰岛素作用的机制发挥的，而CrO42-是研究胰岛素作用相关问题的一种新颖而有用的工具。

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