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首页> 外文期刊>JA Clinical Reports >Goal-directed therapy reduces fluid balance while maintaining hemodynamic stability in intraoperative management of pancreaticoduodenectomy: a retrospective comparative study
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Goal-directed therapy reduces fluid balance while maintaining hemodynamic stability in intraoperative management of pancreaticoduodenectomy: a retrospective comparative study

机译：一项回顾性比较研究，在胰腺十二指肠切除术的术中处理中，目标导向疗法可在维持血流动力学稳定性的同时减少液体平衡：一项回顾性比较研究

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BackgroundGoal-directed therapy (GDT) is beneficial for surgical patients, especially for those undergoing high-risk surgery. However, little has been reported on the hemodynamic effects of GDT in extensive surgery. We conducted a study to determine the impact of GDT on intraoperative management of extensive surgery. FindingsWe retrospectively collected data from 90 patients who underwent pancreaticoduodenectomy: 44 who received intraoperative GDT (GDT group) and 46 who received conventional hemodynamic management (control group). Intraoperative use of fluids and catecholamines and physiologic variables, including mean arterial pressure, heart rate, and urine output, were compared. We also examined the correlation between the amount of fluid administered and urine output. The amount of fluid administered was comparable, and urine output was significantly larger in the GDT group than in the control group. Fluid balance was significantly smaller in the GDT group (49.7 versus 61.7?mL/kg; 95% confidence interval, ??19.5 to ??4.6?mL/kg; P =?0.0019). There was a trend toward higher mean arterial pressure in the GDT group despite lower fluid balance. We found a rank correlation between the amount of fluid administered and urine output in the GDT group (rank correlation coefficient, 0.68; P ConclusionsGDT increased urine output and decreased fluid balance while maintaining hemodynamic stability. The amount of fluid administered and urine output were correlated in the GDT group.
机译：背景技术目标导向疗法（GDT）对外科手术患者尤其是进行高风险手术的患者有益。但是，关于GDT在广泛手术中的血液动力学影响的报道很少。我们进行了一项研究，以确定GDT对广泛手术的术中管理的影响。研究结果我们回顾性收集了90例行胰十二指肠切除术的患者的数据：44例接受了术中GDT的患者（GDT组）和46例接受了常规血液动力学治疗的患者（对照组）。比较术中使用的液体和儿茶酚胺以及生理变量，包括平均动脉压，心率和尿量。我们还检查了输液量与尿量之间的相关性。输液量相当，GDT组的尿量显着大于对照组。 GDT组的体液平衡明显更小（49.7对61.7mL / kg; 95％置信区间为19.5至4.6mL / kg; P = 0.0019）。尽管体液平衡较低，但GDT组仍存在平均动脉压升高的趋势。我们发现GDT组的输液量与尿量之间存在等级相关性（秩相关系数为0.68; P结论）GDT在保持血液动力学稳定的同时增加了尿液的排出量并降低了血液平衡。 GDT组。

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