TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS

MOTOHATSU FUJIWARA; SEIMEI OSUMI

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TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS

机译：外源性和内源性累积的大鼠八甲胺的组织分布

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References(12) The presence of octopamine in the secretion of the salivary gland of Octopus vulgaris was first demonstrated by Erspamer (1). Kakimoto and Armstrong (2) showed the occurrence of this amine in various tissues of rabbits treated with monoamine oxidase inhibitors. However, paper chromatographic studies of the tissue level of octopamine did not give precise information about small changes of the amine level. Based upon the reaction that octopamine is converted quantitatively to p-hydroxybenzaldehyde by periodate oxidation in ammonia alkaline medium (3), the amount of tissue and blood octopamine could be evaluated by measuring the ultraviolet absorption of the oxidation product. In the present experiments the distribution of exogenously administered octopamine and the accumulation of endogenous octopamine after a monoamine oxidase inhibitor were studied in the blood, brain stem, heart, submaxillary glands, spleen and stomach of the rat.

机译：参考文献（12）Erspamer（1）首次证实八达通唾液腺分泌物中存在章鱼胺。 Kakimoto和Armstrong（2）表明，用单胺氧化酶抑制剂治疗的兔子的各种组织中都存在这种胺。然而，对章鱼胺组织水平的纸色谱研究未能给出有关胺水平微小变化的准确信息。根据在氨碱性介质（3）中高碘酸盐氧化使章鱼胺定量转化为对羟基苯甲醛的反应，可以通过测量氧化产物的紫外线吸收来评估组织和血液中的章鱼胺的量。在本实验中，研究了在大鼠的血液，脑干，心脏，上颌下腺，脾脏和胃中单胺氧化酶抑制剂后外源性施用的章鱼胺的分布和内源性章鱼胺的积累。

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《Japanese Journal of Pharmacology》 |1969年第2期|共页
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MOTOHATSU FUJIWARA; SEIMEI OSUMI;
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TISSUE DISTRIBUTION OF EXOGENOUSLY ADMINISTERED, AND ENDOGENOUSLY ACCUMULATED OCTOPAMINE IN RATS

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