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首页> 外文期刊>Japanese Journal of Pharmacology >THE ACTIONS OF D 600, ASPAMINOL AND PAPAVERINE ON CALCIUM-, POTASSIUM- AND HISTAMINE-INDUCED CONTRACTIONS OF ISOLATED RABBIT BASILAR ARTERY, AORTA, TAENIA COLI AND TRACHEAL SMOOTH MUSCLE
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THE ACTIONS OF D 600, ASPAMINOL AND PAPAVERINE ON CALCIUM-, POTASSIUM- AND HISTAMINE-INDUCED CONTRACTIONS OF ISOLATED RABBIT BASILAR ARTERY, AORTA, TAENIA COLI AND TRACHEAL SMOOTH MUSCLE

机译：D 600，天冬酰胺和帕帕汀对钙，钾和组胺诱导的离体兔基底动脉，主动脉，TA虫和气管平滑肌收缩的作用

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References(33) Cited-By(4) The effects of D 600, Aspaminol (1, 1-diphenyl-3-piperidinobutanol hydrochloride) and papaverine on CaCl2-, KCl- and histamine-induced contractile responses of isolated rabbit basilar artery, aorta, taenia coli and tracheal smooth muscle were compared with each other. D 600 reduced CaCl2-induced maximal responses in basilar artery and aorta, and parallelly shifted the concentration-response curves for CaCl2 to the right in taenia coli and trachea. D 600 also reduced histamine-induced maximal contractions in basilar artery and taenia coll. These reductions were not reversed by increasing CaCl2 concentration in bathing fluids. High concentration of D 600 parallelly shifted the concentration-response curve for histamine to the right in aorta. Like D 600, Aspaminol, a nonspecific smooth muscle relaxant, parallelly shifted the concentration-response curve for histamine in aorta. Papaverine parallelly shifted the concentration-response curve for CaCl2 in taenia coli and reduced the maximal responses in other tissues. Papaverine also reduced histamine-induced maximal responses in basilar artery, aorta and taenia coll. Influences of these smooth muscle relaxants on histamine-induced contraction in Ca-free buffer solution and on KCl-induced contraction in normal and high Ca (Ca: 12.5 mM) buffer solution were also studied. From the results obtained in this study, the effects of smooth muscle relaxants are considered to vary with the type of smooth muscle or the condition eliciting contraction, and the possible mechanisms of the contractions were discussed.
机译：参考文献（33）（4）D 600，Aspaminol（1，1-diphenyl-3-piperidinobutanol hydrochloride）和罂粟碱对CaCl2-，KCl-和组胺诱导的离体兔基底动脉，主动脉收缩反应的影响，虫和气管平滑肌相互比较。 D 600减少了CaCl2诱导的基底动脉和主动脉的最大反应，并使TaCl2和气管中CaCl2的浓度-反应曲线平行向右移动。 D 600还减少了组胺引起的基底动脉和带coll的最大收缩。通过增加沐浴液中的CaCl2浓度并不能逆转这些减少。高浓度的D 600使组胺的浓度-响应曲线平行移动到主动脉的右侧。像D 600一样，非特异性平滑肌松弛剂Aspaminol平行移动了主动脉中组胺的浓度-响应曲线。罂粟碱平行移动了虫中CaCl2的浓度-响应曲线，并降低了其他组织中的最大响应。罂粟碱还减少了组胺引起的基底动脉，主动脉和带结肠的最大反应。还研究了这些平滑肌松弛剂对无钙缓冲溶液中组胺诱导的收缩以及在正常和高钙（Ca：12.5 mM）缓冲溶液中KCl诱导的收缩的影响。从本研究中获得的结果，认为平滑肌松弛剂的效果随平滑肌类型或引起收缩的条件而变化，并讨论了收缩的可能机制。

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