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首页> 外文期刊>Japanese Journal of Pharmacology >Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Thyrotropin-Releasing Hormone-Like Immunoreactivity in the Cerebral Cortex and Hippocampus of Aged Rats
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Effect of a Novel Prolyl Endopeptidase Inhibitor, JTP-4819, on Thyrotropin-Releasing Hormone-Like Immunoreactivity in the Cerebral Cortex and Hippocampus of Aged Rats

机译：新型脯氨酰内肽酶抑制剂JTP-4819对老年大鼠大脑皮层和海马中促甲状腺激素释放激素样免疫反应的影响

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References(15) Cited-By(13) We investigated the effects of a novel prolyl endopeptidase inhibitor, JTP-4819 ((S)-2-[[(S)-2-(hydroxyacetyl)-1-pyrrolidinyl]carbonyl]-N-(phenylmethyl)-1-pyrrolidinecarboxamide), on thyrotropin-releasing hormone (TRH)-like immunoreactivity (TRH-LI) in the cerebral cortex and hippocampus of aged rats. The TRH-LI content of both brain regions in aged rats was significantly lower than that in young rats. A single oral dose of JTP-4819 (3 mg/kg) restored the cortical TRH-LI content in aged rats, while doses of 0.3-3 mg/kg restored it in the hippocampus. Repeated oral administration of JTP-4819 at a dose of 1 mg/kg for 21 days produced a significant increase of TRH-LI in the cerebral cortex, while it did so in the hippocampus at doses of 0.3 and 1 mg/kg. Our findings suggest that JTP-4819 may improve the functioning of TRHergic neurons, which deteriorate with senescence.
机译：参考文献（15）By-By（13）我们研究了新型脯氨酰内肽酶抑制剂JTP-4819（（S）-2-[[[（S）-2-（羟乙酰基）-1-吡咯烷基]羰基]- N-（（苯基甲基）-1-吡咯烷甲酰胺）对老年大鼠大脑皮层和海马中促甲状腺激素释放激素（TRH）样免疫反应（TRH-LI）的影响。老年大鼠两个脑区的TRH-LI含量均明显低于年轻大鼠。 JTP-4819的单次口服剂量（3 mg / kg）可恢复衰老大鼠的皮质TRH-LI含量，而海马中的0.3-3 mg / kg剂量可恢复其皮质TRH-LI含量。以1 mg / kg的剂量重复口服JTP-4819达21天，在大脑皮层中TRH-LI显着增加，而在海马中以0.3和1 mg / kg的剂量显着增加。我们的发现表明，JTP-4819可能会改善TRH能神经元的功能，后者会随着衰老而恶化。

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