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Monitoring Interest in Herpes Zoster Vaccination: Analysis of Google Search Data

机译:监测带状疱疹疫苗接种的兴趣:Google搜索数据分析

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Background: A new recombinant subunit vaccine for herpes zoster (HZ or shingles) was approved by the United States Food and Drug Administration on October 20, 2017 and is expected to replace the previous live attenuated vaccine. There have been low coverage rates with the live attenuated vaccine (Zostavax), ranging from 12-32% of eligible patients receiving the HZ vaccine. Objective: This study aimed to provide insight into trends and potential reasons for interest in HZ vaccination. Methods: Internet search data were queried from the Google Health application programming interface from 2004-2017. Seasonality of normalized search volume was analyzed using wavelets and Fisher’s g test. Results: The search terms “shingles vaccine,” “zoster vaccine,” and “zostavax” all exhibited significant periodicity in the fall months ( P .001), with sharp increases after recommendations for vaccination by public health-related organizations. Although the terms “shingles blisters,” “shingles itch,” “shingles rash,” “skin rash,” and “shingles medicine” exhibited statistically significant periodicities with a seasonal peak in the summer ( P .001), the terms “shingles contagious,” “shingles pain,” “shingles treatment,” and “shingles symptoms” did not reveal an annual trend. Conclusions: There may be increased interest in HZ vaccination during the fall and after public health organization recommendations are broadcast. This finding points to the possibility that increased awareness of the vaccine through public health announcements could be evaluated as a potential intervention for increasing vaccine coverage.
机译:背景:2017年10月20日,美国食品药品监督管理局批准了一种新的带状疱疹重组亚单位疫苗(HZ或带状疱疹),有望取代以前的减毒活疫苗。减毒活疫苗(Zostavax)的覆盖率很低,占接受HZ疫苗的合格患者的12-32%。目的:本研究旨在提供对HZ疫苗接种兴趣的趋势和潜在原因的见解。方法:从2004-2017年从Google Health应用程序编程界面中查询互联网搜索数据。使用小波和Fisher检验对归一化搜索量的季节性进行了分析。结果:搜索词“带状疱疹疫苗”,“带状疱疹疫苗”和“ zostavax”在秋季月份均表现出明显的周期性(P <.001),在公共卫生相关组织建议进行疫苗接种后,其急剧增加。尽管术语“带状疱疹”,“带状疱疹”,“带状疱疹”,“皮疹”和“带状疱疹药物”在统计学上具有显着的周期性,并在夏季出现季节性高峰(P <.001),但术语“带状疱疹”传染性,“带状疱疹疼痛”,“带状疱疹治疗”和“带状疱疹症状”并未显示出年度趋势。结论:秋季和公共卫生组织建议发布后,人们对HZ疫苗的兴趣可能增加。这一发现表明,有可能通过公共卫生公告来提高对疫苗的认识,可以作为增加疫苗覆盖率的一种潜在干预措施。

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