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首页> 外文期刊>Jornal Brasileiro de Patologia e Medicina Laboratorial >Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations
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Pilocytic astrocytoma of sellar/suprasellar region determining endocrine manifestations

机译：鞍区/上up区的上皮星形细胞瘤决定内分泌表现

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Pilocytic astrocytoma (PA) is a grade I glial neoplasm arising mainly in the cerebellum of children. Herein, the authors report a case of PA in a 21 year-old male patient, who presented headache, vomiting and delayed pubertal development. Serum level of cortisol and testosterone corresponded to 32.8 ug/dl and 0.19 ng/ml, respectively. The computed tomography/magnetic resonance (CT/RM) imaging showed an expansive process compromising suprasellar/hypothalamic region and determining hydrocephalus. The patient underwent resection of the process. Histological evaluation revealed a glial neoplasm constituted by loose glial tissue, small microcysts, areas of dense piloid tissue and Rosenthal fibers. The neoplastic cells were immunoreactive for glial fibrillary acidic protein (GFAP) and negative for chromogranin and synaptophysin. The diagnosis of PA was then established.
机译：上皮星形细胞瘤（PA）是主要发生于儿童小脑的I级神经胶质瘤。在此，作者报告了一名21岁男性患者的PA病例，该患者出现头痛，呕吐和青春期发育延迟。血清皮质醇和睾丸激素水平分别对应于32.8 ug / dl和0.19 ng / ml。计算机体层摄影/磁共振（CT / RM）成像显示肿胀过程损害了鞍上/下丘脑区域并确定了脑积水。病人接受了手术切除。组织学评估显示，神经胶质瘤由神经胶质组织疏松，微囊肿，致密的倍数体组织和罗森塔尔纤维组成。肿瘤细胞对神经胶质纤维酸性蛋白（GFAP）具有免疫反应性，而嗜铬粒蛋白和突触素则呈阴性。然后确定了PA的诊断。

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