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化学‐力学エネルギー変換(有機エンジン)を用いた自律駆動型薬物放出システム

机译:利用化学机械能转换的自动驱动药物释放系统(有机发动机)

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摘要

A novel drug-injection system that utilities direct chemo-mechanical energy conversion was fabricated and demonstrated for feedback control of glucose level. The system consists of two integrated units, decompression unit and drug release unit. The decompression unit was fabricated by separating a cylindrical cell into a top cell (gas phase) and a bottom cell (liquid phase) by glucose oxidase (GOD) enzyme immobilized membrane. The enzyme membrane recognizes glucose and converts chemical energy into pressure decreaese by consuming oxgen. The linear correlation between glucose concentration and de-pressure slope of the top cell was revealed as applying glucose solution to the bottom cell. The drug release unit which utilizes the energy of the decompression unit as a power source was evaluated by recording its release actions. The system is expected to be used in intelligent actuators without external energy.
机译:实用新型直接化学机械能转换的新型药物注射系统被制造出来,并被证明可用于葡萄糖水平的反馈控制。该系统由两个集成单元组成,减压单元和药物释放单元。通过用葡萄糖氧化酶(GOD)酶固定膜将圆柱形小室分成顶部小室(气相)和底部小室(液相)来制造减压单元。酶膜识别葡萄糖,并通过消耗氧气将化学能转化为压力下降。通过将葡萄糖溶液施加到底部细胞,揭示了顶部细胞的葡萄糖浓度和减压斜率之间的线性相关性。通过记录减压单元的释放动作来评价利用减压单元的能量作为动力的药物释放单元。该系统有望用于没有外部能量的智能执行器。

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