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首页> 外文期刊>Journal of Advanced Science >Calibration of infrared video-oculography by using bioadhesive phosphorescent particles for accurate measurement of vestibulo-ocular reflex in mice
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Calibration of infrared video-oculography by using bioadhesive phosphorescent particles for accurate measurement of vestibulo-ocular reflex in mice

机译：通过使用生物粘附性磷光颗粒对红外眼动仪进行校准，以精确测量小鼠的前庭眼反射

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摘要

Eye movements are known to be well-quantitative indices to analyze a variety of neurological deficits as well as mechanisms for controlling motor systems both in scientific and clinical researches. In this study, a novel method we developed to measure the eye movement in mice, using bioadhesive polymer-coated phosphorescent particles, was applied for the calibration of the conventional video-oculography that tracks the pupil. We tested the vestibulo-ocular reflex, a reflexive eye movement observed across various species, and compared the values measured by the new method with ones measured by the conventional video-oculography. We found the difference between them was significant when the size of the pupil became small whereas those values were similar when the size of the pupil was relatively large. Our results suggest that there is a calibration factor related to the size of the pupil to improve the accuracy of the video-oculography and a potential benefit of our novel method to measure eye movements in rodents.
机译：众所周知，眼球运动是分析各种神经系统缺陷以及控制科学研究和临床研究中的运动系统的机制的量化指标。在这项研究中，我们开发了一种使用生物粘附性聚合物涂层的磷光颗粒来测量小鼠眼球运动的新方法，用于校准跟踪瞳孔的常规视频眼动仪。我们测试了前庭眼反射，即在各种物种中观察到的自反眼动，并将通过新方法测得的值与通过常规视频眼动仪测得的值进行了比较。我们发现，当瞳孔尺寸变小时，它们之间的差异是显着的;而当瞳孔尺寸相对较大时，这些值是相似的。我们的结果表明，存在一个与瞳孔大小相关的校准因子，可以提高视频眼图的准确性，而我们的新颖方法可以测量啮齿动物的眼动，因此具有潜在的优势。

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