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首页> 外文期刊>Journal of AIDS and HIV Research >Factors affecting adherence to antiretroviral treatment among patients living with HIV/AIDS, in Bale zone, south eastern Ethiopia
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Factors affecting adherence to antiretroviral treatment among patients living with HIV/AIDS, in Bale zone, south eastern Ethiopia

机译：在埃塞俄比亚东南部的贝尔地区，影响艾滋病毒/艾滋病患者坚持抗逆转录病毒治疗的因素

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Adherence to antiretroviral therapy is of critical importance because even minor deviations from the prescribed regimen can result in viral resistance. Multiple factors influence adherence among people living with human immune virus. But at present little is known about the patient’s experience and adherence when taking such complex regimens. The major aim of the study was to assess factors associated with antiretroviral treatment adherence among people living with human immune virus ?A facility based cross-sectional study design was used, with systematic sampling technique on 300 adult patients on antiretroviral therapy. Factors associated with adherence to antiretroviral drugs were analyzed with bivariate and multivariate logistic regression. A total of 300 patients on antiretroviral therapy involved in this research and despite requirement of complete or near complete adherence to antiretroviral therapy only 205(68.3%) were found to be adherent. The bivariate and multivariate logistic regression showed that factors like mild depression (AOR=3.24) 95% CI(2.04-8.67), moderate depression (AOR=3.06) 95%CI(1.61-5.67), alcohol abuse (COR=2.562) p=0.049, current khat chewing (COR=2.85) p=0.025, disclosure status (COR=0.426) p=0.004, presence of opportunistic infection (AOR=5.44) 95%CI(1.833-16.10), and presence of comorbid disease (COR=4.256) p=0.002 showed association to adherence to antiretroviral therapy. Generally about three out ten patients on antiretroviral therapy were found to be non-adherent to antiretroviral regimen in Bale zone. Depression and the presence of opportunistic infection are adversely linked to adherence status of these patients.
机译：坚持抗逆转录病毒疗法至关重要，因为即使与规定的治疗方案稍有偏差也会导致病毒耐药。多种因素影响人类免疫病毒感染者之间的依从性。但是目前，对于采用这种复杂疗法的患者的经历和依从性知之甚少。该研究的主要目的是评估人类免疫病毒感染者与抗逆转录病毒疗法依从性相关的因素？采用基于设施的横断面研究设计，系统地对300名接受抗逆转录病毒疗法的成年患者进行抽样研究。通过双因素和多因素logistic回归分析与抗逆转录病毒药物依从性相关的因素。总共有300名接受抗逆转录病毒治疗的患者参与了这项研究，尽管要求完全或接近完全遵守抗逆转录病毒治疗的要求，但发现只有205名患者（68.3％）是依从性的。二元和多元logistic回归显示，轻度抑郁症（AOR = 3.24）95％CI（2.04-8.67），中度抑郁症（AOR = 3.06）95％CI（1.61-5.67），酗酒（COR = 2.562）p等因素= 0.049，当前卡塔叶咀嚼（COR = 2.85）p = 0.025，披露状态（COR = 0.426）p = 0.004，存在机会性感染（AOR = 5.44）95％CI（1.833-16.10），并且存在合并症（ COR = 4.256）p = 0.002表明与抗逆转录病毒疗法的依从性相关。通常，在Bale区发现接受抗逆转录病毒疗法的患者中，约有十分之三不遵循抗逆转录病毒疗法。抑郁症和机会性感染的存在与这些患者的依从性状况存在不利关系。

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