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首页> 外文期刊>Journal of AIDS and HIV Research >Effect of combination therapy of haart and -zam herbal preparation for HIV infection in rats
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Effect of combination therapy of haart and -zam herbal preparation for HIV infection in rats

机译：哈特-扎姆草药制剂联合治疗对大鼠HIV感染的影响。

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It is not uncommon seeing patients taking orthodox and herbal remedies concurrently for the same disease. The concern of many health practitioners is the safety of such combination therapy especially when there is a possibility of adverse drug reaction as a result of drug-drug interaction. This study focussed on drug interactions of α-Zam (herbal antiretroviral drug) when combined with lamivudine, zidovudine and nevirapine (highly active anti-retroviral therapy) using an animal model. Wistar rats were divided into 5 groups (10 rats per group) and were administered with 400 mg/kg (α-Zam), 800 mg/kg (α-Zam), 400 mg/kg (α-Zam) +HAART, 800 mg/kg (α-Zam) +HAART and normal saline. All administration was done once daily orally via canula to the 4 different groups respectively with the 5th group as control for 6 days. All wistar rats in all groups were observed daily for change in behaviour. On the 7th day, all rats were bled via retro-orbital plexus under light diethyl ether anaesthesia. The blood samples were analysed for haematological (haemoglobin concentration, white blood cell, red blood cell, platelet and lymphocyte counts) and biochemical (electrolytes, urea, creatinine, lipid profile, liver and renal functions tests) parameters. Some organs were also harvested for histological examinations. There was neither mortality nor behavioural abnormality observed in all the drug administered rats. There were some mild atrophic changes in liver and kidney with hyper-cellularity of bone marrow but no statistically significant difference (P>0.05) were found in all blood (haematological and biochemical) parameters in rat groups administered combination therapy (herbal concoction+ HAART). It was concluded that the combined administration of α-zam and HAART (lamivudine, zidovudine and nevirapine) did not cause any significant adverse drug reaction. Rather beneficial effects were observed in amelioration of side-effects associated with the herbal concoction and orthodox anti-viral medicines.
机译：看到病人同时针对同一疾病服用正统疗法和草药疗法并不少见。许多健康从业者所关心的是这种联合疗法的安全性，尤其是当由于药物相互作用引起药物不良反应时。这项研究集中于使用动物模型与拉米夫定，齐多夫定和奈韦拉平（高效抗逆转录病毒疗法）联合使用时，α-Zam（草药抗逆转录病毒药物）的药物相互作用。将Wistar大鼠分为5组（每组10只大鼠），分别给予400 mg / kg（α-Zam），800 mg / kg（α-Zam），400 mg / kg（α-Zam）+ HAART，800 mg / kg（α-Zam）+ HAART和生理盐水。所有的给药每天通过插管经口一次地分给4个不同的组，第5组作为对照组，共6天。每天观察所有组中的所有wistar大鼠的行为变化。在第7天，在轻度乙醚麻醉下通过眼眶后丛使所有大鼠放血。分析血液样本的血液学（血红蛋白浓度，白细胞，红细胞，血小板和淋巴细胞计数）和生化（电解质，尿素，肌酐，脂质分布，肝和肾功能测试）参数。还收集了一些器官用于组织学检查。在所有给药的大鼠中均未观察到死亡率或行为异常。联合用药（草药混合+ HAART）组大鼠的肝脏和肾脏有一些轻度的萎缩性改变，并伴有骨髓细胞过多，但所有血液（血液学和生化指标）参数均无统计学意义（P> 0.05）。结论是，α-zam和HAART（拉米夫定，齐多夫定和奈韦拉平）的联合给药不会引起任何明显的药物不良反应。在改善与草药汤和正统抗病毒药有关的副作用方面观察到了相当有益的作用。

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