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首页> 外文期刊>Journal of AIDS and HIV Research >Change in serum lipid profiles and glucose after switching from stavudine/lamivudine to zidovudine/lamivudine in non-nucleoside reverse transcriptase inhibitors based anti-retroviral regimens in Southern Ethiopia
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Change in serum lipid profiles and glucose after switching from stavudine/lamivudine to zidovudine/lamivudine in non-nucleoside reverse transcriptase inhibitors based anti-retroviral regimens in Southern Ethiopia

机译：在基于埃塞俄比亚南部非核苷类逆转录酶抑制剂的抗逆转录病毒方案中，从司他夫定/拉米夫定改为齐多夫定/拉米夫定后，血清脂质谱和葡萄糖的变化

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Data concerning any difference in serum lipid profiles and glucose level after patients switched from stavudine to zidovudine in Ethiopia is very limited. Seventy eight adults receiving antiretroviral therapy (ART) that included stavudine/lamivudine with either of efavirenz or nevirapine during ART initiation were enrolled. Of these patients, 53 were switched to zidovudine/lamivudineevirapine (NVP-group) and the rest 25 were switched to zidovudine/lamivudine/efavirenz (EFV-group). Serum lipid profiles and glucose were determined after overnight fasting. Dyslipidemia and dysglycaemia were assessed according to the United State National Cholesterol Education program-III guideline. Statistical analysis was done using Statistical Package for Social Sciences (SPSS) Version 20. Of the 78 patients, 39.7% were males and 60.3% were females. At the end of the study follow-up, the prevalence of TC ≥ 200 mg/dl, LDL-c ≥ 130 mg/dl, TG ≥ 150 mg/dl, HDL-c < 40 mg/dl and glucose ≥ 110 mg/dl were higher in EFV group when compared with NVP. About 74.4% patients had at least two laboratory abnormities which is compatible with a diagnosis of dyslipidemia at 12 month of post switch. Four lipid profiles abnormal within a single individual was 16% in EFV and 3.8% in NVP group, p = 0.08. Raised HDL-c concentration was observed in NVP group in both periods when compared with EFV. In addition, patients that switched from d4T/3TC/NVP to AZT/3TC/NVP had a significant change in TC and TG (p = 0.001 for both). Also TC ≥ 200 mg/dl was decreased from 49 to 16% (p = 0.04). Furthermore, sex was significantly and negatively associated with raised TC and TGs among patients using NVP based regimen. Raised HDL-c concentration, decreased proportion of abnormal lipid profiles and abnormal glucose was observed in the NVP group. Based on these findings, NVP may be expected to reduce the risk of cardiovascular diseases.
机译：在埃塞俄比亚从司他夫定转为齐多夫定后，患者血清脂质谱和葡萄糖水平的任何差异的数据非常有限。招募了78名接受抗逆转录病毒治疗（ART）的成年人，其中包括接受抗逆转录病毒治疗（ART）的患者，其中包括司他夫定/拉米夫定联合依非韦伦或奈韦拉平。在这些患者中，有53名改用齐多夫定/拉米夫定/奈韦拉平（NVP组），其余25名改用齐多夫定/拉米夫定/依非韦伦（EFV组）。过夜禁食后测定血清脂质谱和葡萄糖。根据美国国家胆固醇教育计划III指南评估血脂异常和血糖异常。使用社会科学统计软件包（SPSS）第20版进行统计分析。在78例患者中，男性占39.7％，女性占60.3％。在研究结束时，TC≥200 mg / dl，LDL-c≥130 mg / dl，TG≥150 mg / dl，HDL-c <40 mg / dl和葡萄糖≥110 mg / dl的患病率与NVP相比，EFV组的dl更高。约74.4％的患者至少有两个实验室异常，与转换后12个月血脂异常的诊断相符。单个个体中的四个血脂异常在EFV中为16％，在NVP组中为3.8％，p = 0.08。与EFV相比，NVP组在两个时期均观察到HDL-c浓度升高。此外，从d4T / 3TC / NVP切换到AZT / 3TC / NVP的患者的TC和TG均有显着变化（两者均p均为0.001）。 TC≥200 mg / dl也从49％降至16％（p = 0.04）。此外，在使用基于NVP的治疗方案的患者中，性别与TC和TG升高显着负相关。在NVP组中观察到HDL-c浓度升高，异常脂质谱和葡萄糖异常比例降低。基于这些发现，NVP有望降低心血管疾病的风险。

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