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首页> 外文期刊>Journal of Analytical & Bioanalytical Techniques >Medroxyprogesterone Acetate and Progesterone Measurement in Human Serum: Assessments of Contraceptive Efficacy
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Medroxyprogesterone Acetate and Progesterone Measurement in Human Serum: Assessments of Contraceptive Efficacy

机译：醋酸甲羟孕酮和人体血清中的孕酮测定：避孕功效的评估

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Medroxyprogesterone (MPA) is widely used as a contraceptive or for hormone replacement therapy after menopause. The use of MPA, specifically in adolescent girls, is linked to excess weight gain and decreases in bone mineral density. Metabolism and clearance of MPA is highly variable making this agent a candidate for individualized dosing strategies which could possibly decrease unwanted side effects. MPA has been measured in animal tissues and fluids for many years as a contaminant resulting from the use of growth hormones in food animals.MPA has been measured by radioimmunoassay, gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS/MS). LC-MS/MS techniques have proven to be both more specific than radioimmunoassay and required much simpler sample preparation techniques than GC-MS. Here we describe an LC-MS/MS method specifically designed for monitoring MPA and progesterone levels in human serum. The technique in this report involves minimal sample preparation and yields results with precision and accuracy suitable for clinical use.
机译：甲羟孕酮（MPA）被广泛用作更年期后的避孕药或激素替代疗法。 MPA的使用（特别是在青春期女孩中）与体重增加过多和骨矿物质密度降低有关。 MPA的代谢和清除率高度可变，因此该药物可能成为个体给药策略的候选药物，可能会减少不良副作用。多年来在动物组织和体液中已检测到MPA作为食用动物生长激素产生的污染物.MPA已通过放射免疫分析，气相色谱-质谱（GC-MS）和液相色谱-质谱（ LC-MS / MS）。事实证明，LC-MS / MS技术比放射免疫分析更具特异性，并且比GC-MS需要更简单的样品制备技术。在这里，我们描述了一种专为监测人血清中MPA和孕酮水平而设计的LC-MS / MS方法。本报告中的技术涉及最少的样品制备，并以适合临床使用的精确度和准确性产生结果。

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