Responses of Airway Epithelium to Environmental Injury: Role in the Induction Phase of Childhood Asthma

Kumar Rakesh K.; Siegle Jessica S.; Kaiko Gerard E.; Herbert Cristan; Mattes Joerg E.; Foster Paul S.

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Responses of Airway Epithelium to Environmental Injury: Role in the Induction Phase of Childhood Asthma

机译：气道上皮对环境损伤的反应：在儿童哮喘诱导期中的作用

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The pathogenesis of allergic asthma in childhood remains poorly understood. Environmental factors which appear to contribute to allergic sensitisation, with development of a Th2-biased immunological response in genetically predisposed individuals, include wheezing lower respiratory viral infections in early life and exposure to airborne environmental pollutants. These may activate pattern recognition receptors and/or cause oxidant injury to airway epithelial cells (AECs). In turn, this may promote Th2 polarisation via a “final common pathway” involving interaction between AEC, dendritic cells, and CD4.

机译：儿童过敏性哮喘的发病机理仍知之甚少。在遗传易感人群中，Th2偏向于免疫反应的发展似乎有助于过敏性致敏的环境因素包括在生命早期喘息下呼吸道病毒感染和暴露于空气传播的环境污染物。这些可能会激活模式识别受体和/或对气道上皮细胞（AEC）造成氧化剂损伤。反过来，这可能会通过涉及AEC，树突状细胞和CD4之间相互作用的“最终共同途径”促进Th2极化。

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《Journal of Allergy》 |2011年第2期|共页
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Kumar Rakesh K.; Siegle Jessica S.; Kaiko Gerard E.; Herbert Cristan; Mattes Joerg E.; Foster Paul S.;
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1. Early and late phase asthmatic response in lower airways of cat-allergic asthmatic patients--a comparison between experimental and environmental allergen challenge. [J] . Arvidsson MB, Lowhagen O, Rak S Allergy . 2007,第5期

机译：猫过敏性哮喘患者下呼吸道的早期和晚期哮喘反应-实验和环境过敏原挑战之间的比较。
2. The Role of the Extracellular Matrix Protein Mindin in Airway Response to Environmental Airways Injury (Retraction of vol 119, pg 1403, 2011) [J] . Frush Sarah, Li Zhuowei, Potts Erin N., Environmental health perspectives. . 2016,第4期

机译：细胞外基质蛋白Mindin在气道对环境气道伤害的反应中的作用（第119卷撤消，第1403页，2011年）
3. Retraction: “The Role of the Extracellular Matrix Protein Mindin in Airway Response to Environmental Airways Injury” [J] . Sarah Frush, Zhuowei Li, Erin N. Potts, Environmental health perspectives. . 2016,第4期

机译：收回：“细胞外基质蛋白Mindin在气道对环境气道伤害的反应中的作用”
4. Epithelial Damage in the Airways during Acute Exacerbations of Childhood Asthma [C] . Y. Yamada, S. Yoshihara, O. Arisaka Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：在儿童哮喘的急性加剧期间气道中的上皮损伤
5. New insights on the mechanisms of airway epithelium in response to toxicants [D] . Lee, Yong Chan 2007

机译：毒物对气道上皮发生作用机理的新见解
6. Responses of Airway Epithelium to Environmental Injury: Role in the Induction Phase of Childhood Asthma [O] . Rakesh K. Kumar, Jessica S. Siegle, Gerard E. Kaiko, 2011

机译：气道上皮对环境损伤的反应：在儿童哮喘诱导期中的作用
7. Responses of Airway Epithelium to Environmental Injury: Role in the Induction Phase of Childhood Asthma [O] . Kumar, Rakesh K., Siegle, Jessica S., Kaiko, Gerard E., 2011

机译：气道上皮对环境损伤的反应：在儿童哮喘诱导期中的作用
8. Acute Airway Injury and Response: Combined Effect of Smoke and CombustionProducts on Mucin Gene Expression and Regulated Mucin Production in the Tracheal-Bronchial Epithelium (CIC3) [R] . Bhattacharyya, S. 1997

机译：急性气道损伤和反应：烟雾和燃烧产物对气管 - 支气管上皮细胞（CIC3）中粘蛋白基因表达和调节粘蛋白产生的联合作用

Responses of Airway Epithelium to Environmental Injury: Role in the Induction Phase of Childhood Asthma

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