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首页> 外文期刊>Journal of Allergy >The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly
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The Asthma-COPD Overlap Syndrome: A Common Clinical Problem in the Elderly

机译：哮喘-COPD重叠综合征：老年人的常见临床问题

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Many patients with breathlessness and chronic obstructive lung disease are diagnosed with either asthma, COPD, or—frequently—mixed disease. More commonly, patients with uncharacterized breathlessness are treated with therapies that target asthma and COPD rather than one of these diseases. This common practice represents the difficulty in distinguishing these disorders clinically, particularly in patients with a history that does not easily differentiate asthma from COPD. A common clinical scenario is an older former smoker with partially reversible or fixed airflow obstruction and evidence of atopy, demonstrating “overlap” features of asthma and COPD. We stress that asthma-COPD overlap syndrome becomes more prevalent with advancing age as patients respond less favorably to guideline-recommended drug therapy. We review the similarities and differences in clinical characteristics between these disorders, and their physiologic and inflammatory profiles within the context of the aging patient. We underscore the difficulties in differentiating asthma from COPD in current or former smokers, share our institutional experience with overlap syndrome, and highlight the need for new research to better characterize and investigate this important clinical phenotype.
机译：许多患有呼吸困难和慢性阻塞性肺疾病的患者被诊断患有哮喘，COPD或（通常）混合性疾病。更常见的是，患有气喘异常的患者可以选择针对哮喘和COPD的疗法，而不是针对其中一种疾病的疗法。这种常规做法代表了临床上难以区分这些疾病的困难，特别是在那些不容易将哮喘与COPD区分的病史的患者中。一种常见的临床情况是年龄较大的前吸烟者，其部分可逆或固定的气流阻塞，并具有特应性的迹象，表明哮喘和COPD具有“重叠”特征。我们强调，随着患者年龄的增长，哮喘-COPD重叠综合征会越来越普遍，因为患者对指南推荐的药物治疗反应较差。我们审查了这些疾病之间的临床特征的相似性和差异，以及在老年患者的背景下它们的生理和炎症特征。我们强调在现有或以前吸烟者中将哮喘与COPD区别开来的困难，分享我们在重叠综合征方面的机构经验，并强调需要进行新研究以更好地表征和研究这一重要临床表型。

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